Acute exacerbations of chronic obstructive pulmonary disease (ECOPD)
Conditions
Interventions
Control Group:3rd-generation cephalosporins + mucolytics +SABA/SAMA
Modified Ma Xing Shi Gan Decoction Group:Modified Ma Xing Shi Gan Decoction + 3rd-generation cephalosporin + Expectorant + Short-acting bronchodilator
Sponsors
Peking University People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: a. Diagnosed with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD), in accordance with the Expert Consensus on Diagnosis and Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease in China (2023 Revision). b. Diagnosed with Phlegm-Heat Obstructing the Lung Syndrome of COPD, in accordance with the Clinical Terminology of Traditional Chinese Medicine: Syndromes and the 2020 International Clinical Practice Guidelines for Traditional Chinese Medicine. c. Age > 18 years. d. Inpatients. e. Volunteered to participate and signed the Informed Consent Form (ICF).
Exclusion criteria
Exclusion criteria: a. History of allergy to the study drug(s). b. History of comorbid active liver disease. c. Receiving dialysis or known to have moderate-to-severe renal impairment. d. Suspected or confirmed concurrent active systemic infection. e. Comorbid with host immune dysfunction, immunocompromised status, or undergoing immune reconstitution.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hospitalization Days; | — |
Secondary
| Measure | Time frame |
|---|---|
| TCM Syndrome Score;modified Medical Research Council(mMRC);Mechanical ventilation requirement rate;6-minute walk distance;Blood Routine;C-reactive protein(CRP); | — |
Countries
China
Contacts
Public ContactFeng Cuiling
Peking University People's Hospital
Outcome results
None listed