Osteoarthritis
Conditions
Sponsors
The First Affiliated Hospital of Jinan University
Eligibility
Sex/Gender
All
Age
60 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria for KOA Subjects with Kidney Deficiency Syndrome: 1) Age: 60-75 years, regardless of gender. 2) Diagnosed with OA based on X-ray/magnetic resonance imaging (MRI)/clinical symptoms. 3) Kellgren & Lawrence grade between 0 and II. 4) Meeting the Traditional Chinese Medicine (TCM) syndrome differentiation criteria for Kidney Deficiency Syndrome (including Kidney Yin Deficiency, Kidney Yang Deficiency, or Kidney Yin-Yang Deficiency). 5) Agreement to participate in this study and provision of signed informed consent. Inclusion Criteria for Healthy Control Group: 1) Age: 60-75 years, regardless of gender. 2) Not meeting the diagnostic criteria for KOA. 3) Not meeting the diagnostic criteria for Kidney Deficiency Syndrome. 4) In good general health with no other major diseases affecting health status. 5) Agreement to participate in this study and provision of signed informed consent.
Exclusion criteria
Exclusion criteria: 1) Secondary arthritis: Rheumatoid arthritis, ankylosing spondylitis, gouty arthritis, infectious arthritis, traumatic arthritis, etc. 2) Severe joint structural abnormalities: Deformed, disabled, or dysfunctional knee joints. 3) Complicated with systemic diseases: Severe heart, liver, or kidney failure, malignant tumors, blood system diseases, immune deficiencies, tuberculosis, hemophilia, mental disorders, etc. 4) Received joint cavity injections (such as hormones, hyaluronic acid) within the past month, or have been taking long-term hormones or immunosuppressants. 5) Women who may be pregnant or planning to get pregnant.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Kidney Deficiency Score and Therapeutic Effect Evaluation Scale;WOMAC Score Scale;HSS Score Scale;Degree of swelling in the knee joint;VAS pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Measurement of X-ray joint space width and bone spurs;MRI MOAKS Rating Scale; | — |
Countries
China
Contacts
Public Contacthuantian Zhang
The First Affiliated Hospital of Jinan University, No. 613, West Huangpu Avenue, Tianhe District, Guangzhou City, Guangdong Province
Outcome results
None listed