Ovulatory Dysfunction–Related Abnormal Uterine Bleeding in Adolescents
Conditions
Interventions
observation group:The primary intervention administered to participants in the observation group is acupuncture, including: (1) acupuncture alone
(2) acupuncture combined with traditional Chinese medicine (acupuncture plus moxibustion, intradermal acupuncture, and/or Chinese herbal medicine)
and (3) acupuncture combined with Western medical therapies.
control group:The primary treatment administered to participants in the control group consists of hormonal therapies recommended in the 2018 Guideline for the Diagnosis and Management of Abnormal Uter
Sponsors
Institute Of Basic Research In Clinical MedicineChina Academy Of Chinese Medical Sciences
Eligibility
Sex/Gender
Female
Age
10 Years to 19 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria 1.A confirmed diagnosis of abnormal uterine bleeding due to ovulatory dysfunction (AUB-O); 2.Aged 10–19 years (according to the definition of adolescence), with at least one year since menarche; 3.Clear evidence that the bleeding originates from the uterine cavity, rather than from extrauterine sites such as the urethra, anus, vagina, or cervix; 4.Meeting any one of the following criteria: (1) Abnormal menstrual cycle frequency: Irregular menstruation within the first year after menarche is considered a normal transitional phenomenon; From 1 to 3 years after menarche, menstrual cycles 45 days; From =3 years after menarche until the perimenopausal period, menstrual cycles 35 days, or fewer than 8 menstrual cycles per year; More than 1 year after menarche, any single menstrual cycle >90 days; (2) Abnormal menstrual blood loss: Menstrual blood loss >80 mL or <20 mL per cycle; Subjective perception of heavy menstrual bleeding affecting quality of life, or a noticeable reduction in menstrual volume compared with previous cycles, presenting as spotting; (3) Abnormal duration of menstruation: Menstrual bleeding lasting longer than 7 days; (4) Amenorrhea: Primary amenorrhea: absence of menarche by age 15 years, or no menstruation more than 3 years after the onset of breast development; Secondary amenorrhea: cessation of menstruation for three consecutive cycles or for more than 6 months after menarche.
Exclusion criteria
Exclusion criteria: Exclusion Criteria 1.Prepubertal abnormal uterine bleeding caused by precocious puberty, other underlying diseases, or medication use; 2.Pregnancy or pregnancy-related bleeding; 3.Abnormal uterine bleeding caused by uterine structural abnormalities, localized endometrial lesions, coagulation disorders, or iatrogenic factors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the proportion of patients achieving regular menstruation after treatment.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sex hormone levels;Complete blood count parameters;Improvement in menstrual symptoms;Pictorial Blood Assessment Chart (PBAC);Psychological status;Sleep status; | — |
Countries
China
Contacts
Public ContactJia Liu
Institute Of Basic Research In Clinical Medicine China Academy Of Chinese Medical Sciences
Outcome results
None listed