Knee osteoarthritis
Conditions
Interventions
Control Group:The simplified lower limb rehabilitation training is performed in three sets per day, six days per week, for a continuous period of 12 weeks.
Experimental Group:The Three-Step Six-Form Knee Strengthening Exercise practice is performed for three sets per day, six days per week, for a continuous period of 12 weeks.
Sponsors
Affiliated Rehabilitation Hospital of Fujian University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Age between 40-70 years, gender unrestricted; (2) Meet the diagnostic criteria for KOA; (3) Agree to undergo gait collection, blood draw, and MRI imaging, etc.; (4) Voluntary participation and signed informed consent from patients; (5) K-L grading: I-III; (6) Unilateral knee osteoarthritis; (7) BMI < 28.
Exclusion criteria
Exclusion criteria: (1) Patients in the acute attack phase of KOA (reference to the acute attack phase as per the "Chinese Medical Guidelines for the Diagnosis and Treatment of Knee Osteoarthritis (2020 Edition)": knee joint pain (VAS score >7 points), or pain that is persistent, with severe pain making it difficult to sleep; knee joint swelling, functional impairment, limping, or even inability to walk); (2) Patients with severe cognitive impairment or mental illness that affects the assessment of indicators; (3) Patients with other diseases such as rheumatoid arthritis, gout, or osteoporosis; (4) Patients who have had joint cavity injections or surgical procedures within the past month; (5) Patients with other diseases affecting normal lower limb movement and gait; (6) Patients who, in addition to KOA, require the use of analgesic medications due to other chronic or recurrent pain conditions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gait myoelectric indices (root mean square (RMS), median frequency (MF), integrated electromyography (iEMG), activation time of lower limb muscle groups during stance phase, co-activation ratio of muscle groups around the knee joint, etc., including quadriceps femoris, hamstrings, tibialis anterior, gastrocnemius, etc.);Full-length standing X-ray of the lower extremity, force line-related angles: Hip-Knee-Ankle Angle (HKA), Mechanical Axis Distal Femoral Lateral Angle (mMPTA), Distal Femoral Lateral Angle (LDFA), Joint Line Convergence Angle (JLCA).;Gait kinematics selected indices (such as joint three-dimensional angle peak values, etc.);Gait kinetic indices (e.g., joint three-dimensional torque peaks);Superficial Quadriceps Femoris Angle; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum Cartilage Oligomeric Matrix Protein (COMP), Type II Collagen Alpha-1 Chain (COL2A1), SRY-Related High Mobility Group Box Gene 9 (SOX9);Serum bone metabolism indicators: Alkaline Phosphatase (ALP), Receptor Activator of Nuclear Factor ?B Ligand (RANKL), Osteoprotegerin (OPG), Runt-related transcription factor 2 (RUNX2).; | — |
Countries
China
Contacts
Public ContactZheng Zhuo Ming
Fujian University of Traditional Chinese Medicine, First Clinical College
Outcome results
None listed