Diabetic nephropathy
Conditions
Interventions
Losartan group:Losartan potassium 100mg once daily orally.
Bifidobacterium + Losartan Potassium group:Bifidobacterium triple live bacteria capsules, 2 capsules twice daily orally + Losartan potassium 100mg once daily orally.
Traditional Chinese medicine + Losartan potassium group:Traditional Chinese medicine twice daily (oral administration) + Losartan potassium 100mg once daily orally.
Sponsors
Shanghai Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Age between 40 and 75 years old. (2) Meeting the diagnostic criteria. (3) Diagnosed as having kidney yin deficiency syndrome by two traditional Chinese medicine practitioners. (4) Systolic blood pressure controlled below 140 mmHg and diastolic blood pressure below 90 mmHg. (5) Generally healthy with no history of major diseases. (6) Willing to accept this treatment and observation, and having signed the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients with type 1 diabetes leading to early kidney damage. (2) Patients with severe primary diseases of the heart, brain, liver, and hematopoietic system. (3) Patients with kidney damage not caused by diabetes, such as hypertensive nephropathy, glomerulonephritis, urinary tract infections, and other causes. (4) Patients allergic to this medication. (5) Patients with cognitive impairment or those unable to care for themselves. (6) Other conditions or diseases that the researchers believe may pose significant risks to the patient or confound the study results, and therefore warrant exclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Urinary microalbumin;24-hour urine protein quantification;Renin;Angiotensin II;gut microbiota; | — |
Secondary
| Measure | Time frame |
|---|---|
| Kidney function;glomerular filtration rate;Fasting blood glucose;Blood glucose level 2 hours after a meal;Glycated hemoglobin;Traditional Chinese Medicine Syndrome Scoring;BMI; | — |
Countries
china
Contacts
Public Contactyangchaomao
Shanghai Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine
Outcome results
None listed