Post COVID-19 Chronic fatigue syndrome
Conditions
Interventions
Sponsors
the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria for Patients with Post-COVID-19 CFS: 1)Aged =18 years at the time of SARS-CoV-2 infection. 2)Prior confirmed diagnosis of COVID-19 by nasopharyngeal swab RT-PCR test. 3) Fatigue that emerged during the COVID-19 illness or new-onset fatigue following the initial recovery from COVID-19, which has persisted for =6 months. 4) Aged between 18 and 60 years (inclusive) at the time of enrollment. 5) Fulfill the aforementioned 2015 IOM diagnostic criteria for CFS. 6) Right-handed. 7) Native Chinese speaker. 8) Provision of signed informed consent and voluntary participation in the study. Inclusion Criteria for Healthy Subjects: 1) Aged between 18 and 60 years (inclusive). 2) Prior confirmed diagnosis of COVID-19 by nasopharyngeal swab RT-PCR test, with no residual symptoms following recovery from the acute COVID-19 phase. 3) Right-handed. 4) Native Chinese speaker. 5) Voluntary participation in the study with provision of signed informed consent.
Exclusion criteria
Exclusion criteria: Exclusion Criteria for both Post-COVID-19 CFS Patients and Healthy Subjects: 1) Individuals with a pre-pandemic diagnosis of CFS. 2) A history of or current medical conditions that could explain chronic fatigue-like symptoms. 3) Substance abuse or dependence, such as alcohol or drug dependence. 4) Long-term use of immunosuppressants, glucocorticoids, sedative-hypnotics, or antidepressant medications within the past year; or receipt of acupuncture treatment within the past 45 days. 5) Conditions requiring a convalescent period, including: pregnancy, lactation, and within one year postpartum; within one year of major surgery; within one year of recovery from a major infectious disease (e.g., sepsis or pneumonia). 6) Presence of metal or electronic implants in the body, or claustrophobia. 7) Obesity (Body Mass Index > 30). 8) Presence of severe hearing impairment, severe visual impairment or color blindness, or severe motor dysfunction. 9) Recent participation in any other ongoing clinical research studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Multidimensional Fatigue Inventory-20; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fatigue Serverity Scale;The Pittsburgh Sleep Quality Index;Addenbrooke's cognitive examination-III(ACE-III);24-item Hamilton Depression Scale;Generalized Anxiety Disorde-7;Short Form-36 Healthy Survey;Simple Reaction Time Test;Digit Span Forward Test;Symbol Digit Modality Test;Auditory Verbal learning Test;Rey Auditory Verbal learning;Trail Making Test part A, B;Stroop Color Word Test;Controlled Oral Association Word Test;Boston Naming Test;Rey-Osterrieth Complex Figure Test;digit span backward test;Handgrip strength;The lalentcy and amplitude of occipital P100;The lalentcy and amplitude of fronto-central N200;The lalentcy and amplitude of frontal P3a;The lalentcy and amplitude of parietal P3b;The lalentcy and amplitude of frontal N100;The lalentcy and amplitude of frontal N200;The lalentcy and amplitude of parietal P300;The lalentcy and amplitude of fronto-central N200;The lalentcy and amplitude of occipital N200;The lalentcy and amplitude of parietal N200;The nodal degree, degree distribution, assortativity, clustering coefficient, motif, path length, network efficiency, connection density, hubness, centrality and robustness modularity of brain structural covariance network(SCN), white matter structural network and functional network;The concentrations of GSH, GABA, NAA, mI, Glx, Cho, GPC, Cr at bilateral hippocampus;Brain functional connectivity; | — |
Countries
China
Contacts
Public ContactXi Wu
Chengdu University of Traditional Chinese Medicine
Outcome results
None listed