ICU acquired infection
Conditions
Interventions
contrast group:According to the International Guidelines for the Campaign to Save Sepsis (2023 Edition), standard treatments such as anti infection, fluid resuscitation, and organ function support sho
Medication group:On the basis of routine standardized treatment, Huanglian Jiedu Tang is used as an adjuvant therapy(The medication includes 9g Huanglian, 6g Huangqin, 20g Huangqi, 9g Jiaozi, 10g Cinn
Sponsors
Lanzhou University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) Severe patients diagnosed with sepsis who meet the diagnostic criteria for sepsis; (2) Age = 18 years old; (3) Patients who meet the criteria of traditional Chinese medicine and are willing to receive treatment with Huanglian Jiedu Tang and sign an informed consent form; (4) No MDROs were detected in microbial culture upon enrollment (or no evidence of MDROs colonization upon admission).
Exclusion criteria
Exclusion criteria: (1) Pregnant or lactating women; (2) Patients with severe multiple organ failure, tumor cachexia, or organ transplantation combined with long-term use of immunosuppressants, as well as those with an expected survival period of less than 3 months; (3) Individuals who are allergic or intolerant to the ingredients of Huanglian Jiedu Decoction; (4) Patients who have recently been hospitalized in other hospitals and are also infected with MDROs within the hospital; (5) Those who are currently participating in other clinical trials or have completed clinical trials of other drugs for less than 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hospital acquired infections; | — |
Secondary
| Measure | Time frame |
|---|---|
| 28-day all-cause mortality;ICU length of stay;Total hospital length of stay;Duration of mechanical ventilation;Changes in inflammatory markers (CRP, PCT, IL-6);Changes in Sequential Organ Failure Assessment (SOFA) score;Incidence of adverse events; | — |
Countries
China
Contacts
Public ContactLiping Liu
Lanzhou University First Hospital
Outcome results
None listed