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Clinical Observation on the Efficacy of External Traditional Chinese Medicine Therapy Combined with Celecoxib in the Treatment of Knee Osteoarthritis in the Elderly

Research and Application of Key Technologies for Integrated Traditional Chinese and Western Medicine Prevention and Treatment Systems for Chronic Pain and Related Diseases in the Elderly

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2026000093
Enrollment
Unknown
Registered
2026-01-17
Start date
2026-01-16
Completion date
Unknown
Last updated
2026-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis

Interventions

Control Group A:External Traditional Chinese Medicine Therapy
Control Group B:Celecoxib
Experimental Group C:External Traditional Chinese Medicine Therapy combined with celecoxib

Sponsors

Hunan University of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 100 Years

Inclusion criteria

Inclusion criteria: (1) Meet the diagnostic criteria for knee osteoarthritis; (2)Male or female, aged =50 years; (3) Kellgren-Lawrence grade II-III; (4) Persistent or activity-related joint pain for =3 months; (5) Baseline average VAS score =4 points; (6) Voluntarily agree to participate in the trial and sign the informed consent form.

Exclusion criteria

Exclusion criteria: (1) Have secondary KOA, such as post-traumatic arthritis, infectious arthritis of the knee, rheumatoid arthritis, gouty arthritis, knee joint tumors (primary or metastatic), or other related conditions; (2) Have undergone knee surgery; (3) Have severe cardiovascular or cerebrovascular diseases, liver or kidney dysfunction, a history of gastrointestinal ulcers, head trauma, or malignant tumors, or mental disorders affecting brain function, treatment efficacy assessment, or the ability to cooperate with treatment evaluation; (4) Have allergic constitutions or other severe systemic diseases, such as blood disorders, diabetes, skin diseases, or other related conditions; (5) Are allergic to celecoxib; (6) Have used medications or treatments related to the disease within the past month; (7) Have local skin damage or infection from acupuncture, or are unable to accurately locate acupuncture points due to limb defects; (8) Have bleeding tendencies or hereditary bleeding disorders.

Design outcomes

Primary

MeasureTime frame
Visual Analogue Scale;—

Secondary

MeasureTime frame
Western Ontario and McMaster Universities osteoarthritis index,WOMAC;Joint Range of Motion;30-Second Chair Stand Test;40-Meter Fast Walking Test;Response Rate;—

Countries

china

Contacts

Public Contactliumailan

Hunan University of Chinese Medicine

445007305@qq.com18229792024

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: May 1, 2026