Knee osteoarthritis
Conditions
Interventions
Combination Therapy Group:Acupotomy + Platelet-Rich Plasma Therapy
Monotherapy Group:Platelet-Rich Plasma Therapy
Sponsors
Nanchong Central Hospital, Beijing Anzhen Hospital, Capital Medical University (Nanchong Branch)
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: (1) Age: 40-75 years (inclusive), any gender. (2) Diagnostic criteria: 1) Diagnosed with unilateral or bilateral OA according to Chinese Osteoarthritis Diagnosis and Treatment Guidelines. 2) Recurrent knee pain within the past month. 3) X-ray (standing or weight-bearing position) showing joint space narrowing, subchondral bone sclerosis and/or cystic changes, osteophyte formation. 4) Age =50 years. 5) Crepitus during activity. OA diagnosis requires meeting criterion 1) + any two of criteria 2-5. (3) X-ray examination: Kellgren-Lawrence grade 1-4 at screening. For bilateral involvement, the more severe side is selected as target joint; if grades equal, the side with higher WOMAC pain score is selected. (4) WOMAC pain score: =6 points in target joint at screening.
Exclusion criteria
Exclusion criteria: (1) Patients with severe systemic diseases. (2) Comorbid rheumatoid arthritis, rheumatic arthritis, joint trauma, knee infection, or bone/joint tumors. (3) Patients with local infection within 2 weeks before admission, or history of intra-articular injections (sodium hyaluronate, chitosan, corticosteroids, etc.) or steroid use within 4 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analog Scale (VAS) for Pain;Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC);Lysholm Knee Score;Articular cartilage thickness; | — |
Countries
China
Contacts
Public ContactFeng Fang
Nanchong Central Hospital, Beijing Anzhen Hospital, Capital Medical University (Nanchong Branch)
Outcome results
None listed