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Research into the Mechanism of Action of Kidney-Tonifying Chinese Herbal Medicine in Alleviating Reproductive Ageing in Elderly Women

Based on the combined analysis of multi-omics in the follicular microenvironment, we reveal the theoretical basis of "having children at an advanced age" in the "Inner Canon" and explore the intervention of traditional Chinese medicine

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2026000028
Enrollment
Unknown
Registered
2026-01-07
Start date
2026-01-15
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Interventions

Sponsors

The Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
21 Years to 42 Years

Inclusion criteria

Inclusion criteria: 1. Individuals suffering from infertility and undergoing IVF-ET; 2. Individuals aged between 21 and 42 years old; 3. Participants with AFC < 5 and AMH < 1.2 ng/mL; 4. Individuals who have signed the informed consent, voluntarily participate in this study, and actively cooperate.

Exclusion criteria

Exclusion criteria: 1)BMI=28Kg/m2 2) Infertility caused by chromosomal karyotype abnormalities and genetic factors in both parties 3) Suffering from polycystic ovary syndrome, endometriosis, hyperprolactinemia, uterine fibroids and gynecological diseases; Congenital or acquired uterine developmental abnormalities and other contraindications to assisted reproductive technologies; 4) Have used any steroid hormone drugs in the first 3 months of the trial 5) The female party suffers from serious systemic diseases (physical or mental) that cannot withstand pregnancy; Previous history of radiation and chemotherapy 6) Participants in other clinical trials

Design outcomes

Primary

MeasureTime frame
Transcriptomics-proteomics-metabolomics integrated analysis results.;

Secondary

MeasureTime frame
Transcriptomics Analysis Results;Proteomics Analysis Results;Metabolomics analysis results;

Countries

China

Contacts

Public ContactGuo Ying

The Affiliated Hospital of Shandong University of Traditional Chinese Medicine

71000916@sdutcm.edu.cn+86 13864138647

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026