Hepatobiliary surgery cases (including gallstone disease, gallbladder polyps, gallbladder adenomyosis, hepatic cysts, hepatic hemangiomas, hepatic focal nodular hyperplasia, and others)
Conditions
Interventions
blank control group:Placebo patch application + Simulated ultrasound-guided targeted drug delivery
Patch Group:Chinese and Western medicine patch application + simulated ultrasound-mediated targeted drug
Ultrasonic Group:Integrated Chinese and Western Medicine Patch Application + Real Ultrasound-Guided Targeted Drug Delivery
Sponsors
Jiangnan University Affiliated Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Liver and biliary surgery cases (including cholecystolithiasis, cholecystic polyps, adenomyomatosis of the gallbladder, hepatic cysts, hepatic hemangiomas, focal nodular hyperplasia of the liver, etc.), with biochemical tests indicating total bilirubin, transaminases < 2 ULN; (2) Age 18-70 years, without severe heart, lung, brain, liver, kidney, vascular, hematological, or mental diseases; (3) American Society of Anesthesiologists (ASA) classification I–II; (4) Smooth surgical procedure, stable vital signs, no blood transfusion; (5) Subjects agree to participate in the clinical study and sign the informed consent, and the study has been reviewed and approved by the hospital's ethics committee (LS2024350).
Exclusion criteria
Exclusion criteria: (1) history of chronic diarrhea, constipation, inflammatory bowel disease, gastrointestinal tumors, or cardiac pacemaker implantation; (2) severe obesity or malnutrition (BMI > 30 kg/m2 or < 15 kg/m2); (3) history of gastrointestinal or abdominal surgery; (4) use of gastrointestinal motility drugs within one month before surgery; (5) patients with comorbidities such as allergies, rashes, anemia, anxiety, depression, and other difficult-to-correct physical and mental illnesses.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to first postoperative flatus; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative recovery time of bowel sounds.;Postoperative first bowel movement time;Postoperative tolerance time for semi-liquid diet;Postoperative nausea and vomiting incidence rate;24h postoperative abdominal circumference change;24h postoperative VAS pain score;Postoperative 24h core body temperature;Postoperative self-ambulation time;Postoperative 48-hour period psychological depression SDS score;Postoperative 48-hour recovery quality QoR-15 score;Postoperative hospital stay;Serum interleukin-6 (IL-6);Serum Adrenaline (AD);Serum prealbumin; | — |
Countries
China
Contacts
Public ContactChen Enhong
Jiangnan University Affiliated Hospital
Outcome results
None listed