Postoperative delirium after radical gastrectomy
Conditions
Interventions
control group:Patients do not use TEAS or the buccal acupuncture therapy intervention during surgery
TEAS group:After the surgery begins, the patient used the fifth generation HANS transcutaneous acupoint electrical stimulator (JS-502-A type, Beijing) to stimulate the Baihui and Neiguan acupoints for
sham TEAS group:The intervention method is similar to the TEAS group, but only applies electrode patches to acupoints without electricity
the buccal acupuncture therapy group:After anesthesia,the buccal acupuncture (disposable sterile needle 0.18mmX30mm) were administered to the upper and middle Jiao points (located at the intersection
Sponsors
Peking University Cancer Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age greater than or equal to 65 years old; 2.American Society of Anesthesiologists (ASA)physical status of II to III; 3. Intending to perform medium to high-risk III/IV level surgeries, 4.including laparoscopic radical gastrectomy and open radical gastrectomy for gastric cancer; 5. Patients with 2 or more of the following diseases: hypertension, diabetes, coronary heart disease, central nervous system diseases (cerebral infarction, coelomic infarction, white matter lesions), chronic obstructive pulmonary disease; 6. Postoperative plan to admit patients to the intensive care unit
Exclusion criteria
Exclusion criteria: 1. Refusal to participate in this study; 2. Preoperative diagnosis includes dementia, Alzheimer's disease, delirium, and brain metastasis; 3. Unable to communicate or cooperate with magnetic resonance imaging due to language barriers or end-stage illnesses; 4. Patients who cannot tolerate supine position; 5.Patients who cannot detach themselves from oxygen therapy equipment; 6. Patients who are not suitable for magnetic resonance imaging due to the implantation of steel nails, steel plates, metal prostheses, etc. in their bodies; 7.Other researchers consider it inappropriate to be selected (specific reasons should be specified).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative delirium at discharge or within 5 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Assess the Pittsburgh Sleep Quality Index score from postoperative day 1 to day 5 (before discharge);Hospital Anxiety and Depression Scale score;Postoperative pain score;Changes in inflammatory factors related to postoperative delirium compared to preoperative levels;Evaluate Charlson's comorbidity index score;Assessment of Consciousness Status (Delirium assessment method) Score;Integrating brain structure and functional imaging through functional magnetic resonance imaging (fMRI) and EEG techniques, dynamically observing the time-varying mapping relationship of brain functional activity intensity, and evaluating changes in fiber bundle structure connections and functional connections between the hippocampus and prefrontal cortex; | — |
Countries
china
Contacts
Public ContactTan Hongyu
Peking University Cancer Hospital
Outcome results
None listed