Abdominal and Pelvic Cancers
Conditions
Interventions
Blank control group: Simple pelvic and abdominal radiotherapy group:Radiation therapy
Experimental group: Pelvic and abdominal radiotherapy + acupuncture treatment group:Radiation therapy+ Acupuncture therapy
Placebo control group: Pelvic and abdominal radiotherapy + sham acupuncture group:Radiation+ Sham acupuncture therapy
Sponsors
The first affiliated hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Aged between 18 and 75 years old; Patients with pelvic and abdominal malignant tumors that have indications for radiotherapy and are receiving pelvic and abdominal radiotherapy, including those with primary liver cancer, biliary tract malignant tumors, pancreatic cancer, colorectal cancer, cervical cancer, prostate cancer, and bladder cancer; ECOG score of 0 - 1; Liver function classified as Child - Pugh 5 - 7 points; Blood, liver, and kidney functions meet the following conditions: a) Neutrophil count =1.5×10^9/L b) Platelet count =75×10^9/L c) Hemoglobin concentration =90g/L d) Serum albumin concentration =30g/L e) Total bilirubin =50µmol/L f) AST and ALT are less than 5 times the upper limit of the normal range, and ALP is less than 4 times the upper limit of the normal range. g) International normalized ratio =2.3 h) Creatinine is less than 1.5 times the upper limit of the normal range. No severe mental illness or contraindications to acupuncture; Have sufficient cognitive function and language ability to communicate and complete the learning questionnaire; Sign the informed consent form for the clinical tria
Exclusion criteria
Exclusion criteria: Concurrent presence of other malignant tumors or a history of other malignant tumors within 5 years before enrollment; Previous pelvic or abdominal radiotherapy; Evidence of current tumor - related pain; Neuropathic pain not caused by radiotherapy, such as post - herpetic neuralgia, diabetes, HIV infection, spinal cord injury, and other neurological diseases; Previous use of other non - drug pain interventions (such as physiotherapy and other traditional Chinese medicine treatments); Presence of severe infection or coagulation disorders; Inability to tolerate acupuncture; Pregnant or lactating women, or subjects planning to have children within two years; Severe cardiac, renal, or other organ dysfunctions, such as arrhythmia (requiring anti - arrhythmic drugs or pacemaker implantation), uncontrolled hypertension, a history of myocardial infarction within 6 months, a prolonged QT interval of more than 450 ms, and congestive heart failure > NYHA class 2; Other serious diseases, such as alcoholism, drug abuse, or mental and psychological disorders, which may affect informed consent or the ability to cooperate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life score;Emotional state rating;Fatigue score; | — |
Countries
China
Contacts
Public ContactLiu Jiahui
The first affiliated hospital, Sun Yat-sen University
Outcome results
None listed