Chronic atrophic gastritis
Conditions
Interventions
CAG group:Ultrasound of the Popliteal Artery
Control group:none
Sponsors
Institute of Basic Theory of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: II. Inclusion Criteria (1) Control Group Selection 1) Aged 20–60 years, with written informed consent and voluntary participation in the study. 2) No history of systemic organic diseases or infectious diseases, no significant subjective symptoms, and no abnormalities despite occasional mild nonspecific symptoms (1–2). 3) Normal physical examination, electrocardiogram (ECG), and chest X-ray findings; good mental status, consciousness, language, and behavioral cooperation. 4) No severe primary diseases (cardiovascular, hepatic, renal, hematopoietic systems, etc.) or malignant tumors; not pregnant or lactating. 5) No allergy to ultrasound equipment or coupling agents; no implanted cardiac pacemaker; no local plaque, dilation, or intimal thickening in lower limb arteries that could interfere with measurement. (2) Experimental Group Selection Experimental Group (CAG Patients) Inclusion Criteria (Including Tongue Diagnosis and Pulse Diagnosis) 1) Aged 20–60 years, attending digestive outpatient clinics at institutions including Beijing Anzhen Hospital Affiliated to Capital Medical University, voluntarily participating in this study, and signing informed consent. 2) Western medical diagnosis: Undergone gastroscopy and gastric mucosal biopsy within the past 60 days, with pathological confirmation of chronic atrophic gastritis meeting the following pathological staging criteria: Atrophy classification: I Non-metaplastic atrophy: Partial replacement of gastric glandular tissue by fibrous or fibromuscular tissue, or reduction in glandular number due to inflammatory cell infiltration. II Metaplastic atrophy: Replacement of gastric glandular tissue by intestinal metaplastic glands or pseudo-pyloric metaplastic glands. Atrophy Grading: I No atrophy: Normal glandular number. II Mild atrophy: Reduction in intrinsic glands = 1/3 of original total glands. III Moderate atrophy: Reduction in intrinsic glands 1/3–2/3. IV Severe atrophy: Reduction in intrinsic glands > 2/3, with only a few glands remaining or complete disappearance. Intestinal metaplasia grading: I Mild: Metaplastic area = 1/3 of total glandular and surface epithelial area. II Moderate: Metaplastic area 1/3–2/3 of total area. III Severe: Metaplastic area > 2/3 of total area. Atypical Hyperplasia Grading: I Mild: Slightly enlarged, deeply stained nuclei with relatively dense arrangement; mild glandular hyperplasia with mild structural disorganization. Grade II: Moderate: Nuclei enlarged, deeply stained, densely and disorganized; glandular ducts tortuous, branching irregular. Grade III: Severe: Marked cellular atypia, increased nuclear-to-cytoplasmic ratio, chaotic arrangement, indistinguishable from well-differentiated mucosal carcinoma. 3) Traditional Chinese Medicine Diagnosis: Must simultaneously meet the following two criteria: I Diagnostic Key Points (referencing 2017 Consensus on Integrated Chinese and Western Medicine Diagnosis and Treatment of Chronic Atrophic Gastritis, Expert Consensus on TCM Diagnosis and Treatment of Chronic Gastritis, and TCM textbook standards): "Fullness and Distension"Pattern: Predominantly characterized by epigastric distension and fullness; "Gastric pain" pattern: Predominantly characterized by epigastric pain; "Disturbance" pattern: Vague epigastric discomfort resembling pain yet not fully painful, hunger yet not fully hungry, distension yet not fully distended; Some patients present with nonspecific dyspepsia, such as upper abdominal discomfort, fullness,
Exclusion criteria
Exclusion criteria: Exclusion Criteria: I. Concurrent severe primary cardiovascular, hepatic, renal, or hematopoietic system diseases or malignancies; II. Pregnant or lactating women; III. Severe cognitive impairment or psychiatric disorders rendering the subject unable to cooperate with the examination; IV. Allergy to ultrasound coupling agents or presence of a cardiac pacemaker; V. Localized plaque, dilation, or intimal thickening in lower limb arteries affecting measurement of the dorsalis pedis/dorsalis tarsis artery; VI. Unwillingness or inability to complete required examinations and questionnaires for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Doppler hemodynamic parameters of the dorsalis pedis artery (Tuyang pulse);Histological staging and risk stratification of chronic atrophic gastritis based on OLGA;TCM syndrome patterns and excess/deficiency classification in CAG;CAG status (patients with chronic atrophic gastritis vs healthy controls); | — |
Secondary
| Measure | Time frame |
|---|---|
| Age, sex, body mass index (BMI), disease duration;Helicobacter pylori infection status, complete blood count (CBC), blood biochemistry tests;Upper gastrointestinal symptom score; lifestyle factors (smoking, alcohol use, diet, etc.);TCM syndrome/symptom score, tongue appearance/tongue coating, conventional pulse condition; | — |
Countries
China
Contacts
Public Contactwangchao
Institute of Basic Theory of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences
Outcome results
None listed