Vascular Cognitive Impairment
Conditions
Interventions
A Group:Oral donepezil hydrochloride tablets (5mg once a night before bedtime, 4 weeks)
B Group:Donepezil hydrochloride tablets (same as group A) Yiqi Smart Decoction drug composition: astragalus 15g licorice 15g ginseng 15g cohosh 9g kudzu root 9g vitex 4.5g cypress huangbai 3g white pe
Sponsors
Weifang Hospital Of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
45 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1) Meets the diagnostic criteria for Vascular Cognitive Impairment (VCI); 2) Qi deficiency syndrome score = 10 points; 3) Age between 45-79 years, gender; 4) MoCA score: 10-25 points; 5) Possesses the ability to read and write simple texts; 6) Voluntarily participates in this clinical trial and signs the informed consent form. Note: Patients who meet all of the above six criteria may be included in this study.
Exclusion criteria
Exclusion criteria: 1) Cognitive impairment caused by other factors such as coexisting conditions like epilepsy encephalitis head trauma thyroid dysfunction severe anemia and other diseases that may lead to cognitive impairment or dementia; 2) Patients with a history of brain surgery or those scheduled for brain surgery; 3) Patients who cannot accept the study protocol and the medications used; 4) Patients with comorbid severe depression or other serious mental illnesses (such as schizophrenia bipolar disorder etc.); 5) Patients with severe primary diseases and malignancies affecting heart liver kidney hematopoietic system which may impact life expectancy and participation in follow-up; 6) Patients with significant neurological deficits or severe claustrophobia that prevent them from completing relevant examinations; 7) Patients who have participated in other interventional clinical trials in the past three months or are undergoing other interventional treatments that may interfere with the efficacy evaluation of this trial; 8) Patients who are pregnant or have plans to become pregnant within the past year. Note: Any patient who meets any of the above criteria will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Activities of Daily Living;Qi deficiency syndrome score;Mini-Mental State Examination; | — |
Countries
China
Contacts
Public ContactManli Zhao
Weifang Hospital Of Traditional Chinese Medicine
Outcome results
None listed