Decline in memory
Conditions
Interventions
Experimental Group:Yi He Yin Oral Solution
Control Group:Placebo
Sponsors
Xiyuan Hospital of China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Age between 18 and 60 years old; (2) Subjective memory decline as the main complaint, with memory impairment symptoms lasting more than 6 months; (3) The cutoff scores for the Montreal Cognitive Assessment-Basic (MoCA-B) are as follows: =19 points for education below 6 years, =22 points for education between 7 and 12 years, and =24 points for education exceeding 12 years; (4) No regular use of Chinese or Western medical treatments targeting memory decline in the past 30 days, and no intake of Chinese or Western medications for anxiety, depression, sedation, or sleep in the same period; (5) The participant is fully informed and has signed the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Imaging studies indicate significant organic pathological damage to the brain; (2) Other neurological diseases that may affect cognitive function (e.g., Alzheimer's disease, frontotemporal dementia, severe Parkinson's disease) or other conditions that may impact cognitive function (e.g., hypothyroidism, severe anemia, syphilis); individuals with severe neurological deficits unable to complete examinations (e.g., hemiplegia, various forms of aphasia, visual or auditory impairments); severe mental disorders (e.g., depression, schizophrenia, severe anxiety) and epilepsy; individuals whose cognitive function is affected by drugs or poisoning; (3) Alcohol and substance abusers; (4) Participants with a history of allergies or those allergic to Yee Hee Yeen oral solution; (5) Abnormal laboratory parameters: liver and kidney function indicators exceeding 1.5 times the upper limit of normal; (6) Participants currently enrolled in other clinical trials that may influence the evaluation of this study's results; (7) Pregnant women (pregnancy tests must be conducted; those with positive pregnancy results will be excluded).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical Memory Scale Score (Institute of Psychology, Chinese Academy of Sciences developed) Change Memory Quotient; | — |
Secondary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment Basic Scale (MoCA-B) Scoring;Connor-Davidson Resilience Scale (CD-RISC) Score;Activities of Daily Living (ADL) Scoring;Fatigue Assessment Scale (FAS) Scoring;Hamilton Anxiety Rating Scale (HAMA) score;Traditional Chinese Medicine Core Symptoms Assessment Form Scoring; | — |
Countries
China
Contacts
Public ContactMa Xiaojuan
Xiyuan Hospital of China Academy of Chinese Medical Sciences
Outcome results
None listed