Chronic kidney disease stage 4-5 (CKD4-5)
Conditions
Interventions
Control group:Basic treatment
Experimental Group:Basic treatment combined with conventional Chinese herbal enema
Sponsors
Wangjing Hospital China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. In line with the diagnostic criteria of chronic kidney disease stage 4-5 Western medicine and spleen and kidney deficiency, blood stasis and dampness syndrome of TCM syndrome differentiation standard ; 2. According to the literature ('systematic evaluation of traditional Chinese medicine compound retention enema in the treatment of chronic renal failure'), the age was set to be between 18 and 75 years old ( including 18 and 75 years old ) ; 3. patients without renal replacement therapy, conservative treatment ; 4. Inpatients with good compliance and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with chronic kidney disease who had undergone long-term maintenance hemodialysis ; 2. Chronic kidney disease in the presence of pleural effusion, ascites, severe anemia, severe malnutrition, urinary protein more than 3.5g/d ; 3. Patients with emergency dialysis indications such as hyperkalemia, acidosis and uremic encephalopathy that were difficult to correct ; 4. Patients with acute infection, acute attack of cardiovascular disease, hypertensive heart disease, hypertrophic cardiomyopathy, valvular heart disease, ventricular aneurysm, hyperthyroidism, severe heart failure, and cardiac function above grade IV in the past 3 months ; 5. Patients currently taking glucocorticoids or immunosuppressive agents ; 6. Patients with severe intestinal diseases who could not tolerate enema ; 7. Patients with chronic diarrhea and hemorrhoids acute attack, anal fissure, intestinal surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TCM symptom score;P-cresol sulfate;Intestinal fatty acid binding protein; | — |
Secondary
| Measure | Time frame |
|---|---|
| cystatin c;beta 2-microglobulin;Serum creatinine;Urea nitrogen;Estimated glomerular filtration rate; | — |
Countries
China
Contacts
Public ContactTongxia Li
Wangjing Hospital China Academy of Chinese Medical Sciences
Outcome results
None listed