Chronic kidney disease
Conditions
Interventions
Stage 2–4 CKD patient group:All enrolled patients will receive standard symptomatic Western medical treatment, including control of blood pressure, blood glucose, blood lipids, and uric acid
management of anemia
correction of electrolyte and acid–base imbalances
regulation of calcium–phosphorus metabolism
and active prevention and treatment of complications and comorbidities. For Traditional Chinese Medicine (TCM) therapy, patients will be treated with Professor Shudong Yang's self-designed Bushen Qux
one pack taken at a time, morning and evening. All decoctions will be prepared by the Pharmacy Department of Shenzhen Traditional Chinese Medicine Hospital. The treatment course will last for 8 weeks.
Sponsors
Shenzhen Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Patients meeting the diagnostic criteria for CKD stage2-4; (2) Aged =18 and =65 years; (3) Not receiving hemodialysis or peritoneal dialysis.
Exclusion criteria
Exclusion criteria: (1)Current use of glucocorticoids or immunosuppressive agents. (2)Presence of severe comorbidities in other organ systems, including but not limited to heart failure, or dysfunction of the respiratory, digestive, or hematopoietic systems. (3)Recent history of surgery, severe infection, or malignancy. (4)History of organ or bone marrow transplantation. (5)Acute kidney injury secondary to primary disease or drug exposure. (6)Pregnant or lactating women. (7)Participation in another clinical trial involving investigational drugs. (8)Use of antibiotics within 4 weeks prior to enrollment. (9)Consumption of yogurt, probiotics, or other products/medications that may alter gut microbiota within 1 week prior to enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum creatinine; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood urea nitrogen;Bowel movement frequency;Stool consistency and form;Fecal metabolomic and genomic analysis; | — |
Countries
China
Contacts
Public ContactSHUDONG YANG
Shenzhen Traditional Chinese Medicine Hospital
Outcome results
None listed