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Clinical and Mechanistic Study on Qingfei Huatan Decoction in Treating Pulmonary Multidrug-Resistant Bacterial Infections and Its Impact on Gut Microbiota

Clinical and Mechanistic Study on Qingfei Huatan Decoction in Treating Pulmonary Multidrug-Resistant Bacterial Infections and Its Impact on

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2025002516
Enrollment
Unknown
Registered
2025-12-24
Start date
2024-09-01
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary Multidrug-Resistant Bacterial Infection

Interventions

Control group:Sensitive antibiotic anti-infective treatment physical cooling Fluid replacement expectoration asthma relief respiratory support
Experimental Group:Qingfeihuatan Drink Sensitive antibiotic anti-infective treatment physical cooling Fluid replacement expectoration asthma relief respiratory support

Sponsors

Ningxia Hui Autonomous Region Hospital and Research Institute of traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Ages between 18 and 80 gender not limited. 2.Patients with community-acquired or hospital-acquired pneumonia. 3.The etiological culture of qualified specimens identifies the type of infecting pathogen and the drug resistance profile of multidrug-resistant bacteria clearly. 4.Traditional Chinese Medicine (TCM) diagnosis of Qi deficiency with phlegm-heat and blood stasis obstruction syndrome: Main symptoms: Cough shortness of breath or hoarse cough yellow or white phlegm that is dry or sticky fatigue and lack of energy. Secondary symptoms: Chest and rib-side pain red face and body fever thirst with yellow urine dry stools or abdominal bloating. Tongue and pulse: Dark red tongue tortuous sublingual vessels yellow or greasy yellow coating slippery and thin pulse or slippery and thin rapid pulse. Participants who meet the main symptoms one or more secondary symptoms and have one of the tongue and pulse conditions can be diagnosed. 5.Voluntarily participate in this trial provide informed consent and sign a written informed consent form.

Exclusion criteria

Exclusion criteria: 1.Pregnant and breastfeeding women. 2.Acute organ dysfunction involving 3 or more organs. 3.Acute Physiology and Chronic Health Evaluation II (APACHE II) score greater than 20. 4.Allergic to the medication used in this trial. 5.Individuals with severe primary diseases involving the heart liver kidneys and hematopoietic system those in the advanced stages of malignant tumors those with poorly controlled diabetes patients after organ transplantation and patients with mental illness. 6.The investigator deems it inappropriate for the subject to participate in this clinical trial.

Design outcomes

Primary

MeasureTime frame
Effective rate;Bacterial clearance rate;

Secondary

MeasureTime frame
White cell count;Procalcitonin;Interleukin-6;D-dimer;Plasma albumin;CPIS score;Pneumonia absorption score;Reduction rate of TCM symptom score;C-reactive protein;Neutrophil count;28-day mortality;

Countries

P.R.China

Contacts

Public ContactLi Yanni

Ningxia Hui Autonomous Region Hospital and Research Institute of traditional Chinese Medicine

liyanni08qie@163.com+86 184 6510 0710

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026