Hypertension associated with Mild Cognitive Impairment
Conditions
Interventions
electroacupuncture group:Electroacupuncture at GV20(Baihui) GV24(Shenting) and bilateral PC6(Neiguan) ST36(Zusanli) ST40(Fenglong) and LR3(Taichong). After acupuncture manipulation and Deqi electroac
sham-acupuncture group:Five pairs of non-acupoints were selected. Superficial acupuncture (2mm) without acupuncture manipulation was performed, and there was no need of Deqi sensation. Sham-electroacu
Waiting-list group:The waiting-list group was not treated with electroacupuncture for the first 12 weeks, and compensatory treatment was given after 12 weeks, with the same treatment regimen as the el
Sponsors
Chengdu Integrated Traditional Chinese Medicine & Western Medicine Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) It meets the diagnostic criteria of HT and MCI and there is a clear sequential relationship between HT and cognitive impairment with relatively stable blood pressure control; (2) Cognitive decline for more than 3 months and symptoms are relatively stable: Montreal Cognitive Assessment Scale (MOCA) score =18 points and < 26 points; The Clinical Dementia Scale (CDR) score < 1 point. The Activities of Daily Living (ADL) score< 22 points and no more than one item in the individual score =3 points. (3) Age 45 to 75 right-handed; (4) Education level: Primary school (6 years or more) capable of correctly understanding and completing the scales; (4) No acupuncture treatment has been received within the past three months; (5) Patients or their family members who sign the informed consent form and cooperate with the treatment. Note: Only patients who meet all the above criteria simultaneously can be included in this study.
Exclusion criteria
Exclusion criteria: (1) Currently undergoing other treatments that may interfere with cognitive function such as taking medications that affect cognition (donepezil memantine rivaroxamine etc.); (2) Neurological diseases or chronic diseases systemic diseases that have been diagnosed as potentially affecting cognitive function; (3) Imaging findings include multiple infarctions infarctions in important memory regions of the brain or severe white matter lesions (Fazekas score >3) etc. (4) There are secondary hypertension refractory hypertension or clinical complications and target organ damage; (5) Those who have aphasia hearing impairment or muscle strength less than grade 3 and other functional impairments and are unable to cooperate with the test; (6) Patients with diabetes or those with a body mass index (BMI) 35 scores); (8) Those with bleeding disorders or skin diseases; (9) Drug addicts smokers and heavy drinkers; (10) Women who are menstruating pregnant planning to become pregnant or breastfeeding; (11) Has received any acupuncture treatment within 3 months or participated in other clinical studies. Note: Any patient who meets any of the above conditions will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment (MoCA); | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination(MMSE);verbal fluency test, VFT;Blood pressure;Cortical oxygenated hemoglobin change value;the shape trail test, STT;Auditory Verbal Learning Test; | — |
Countries
China
Contacts
Public ContactXiao Luo
Chengdu Integrated Traditional Chinese Medicine & Western Medicine Hospital
Outcome results
None listed