Primary Chronic Headache
Conditions
Interventions
Chinese Medicine Group: Toutong Jieyu Tongluo Formula
Western Medicine Group: Flunarizine Hydrochloride Capsules (5 mg per capsule), 1 capsule nightly.
Sponsors
Xinhua Hospital of Zhejiang Province
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients who meet all of the following criteria are eligible for inclusion in this trial: (1) Meet the diagnostic criteria for primary chronic headache according to the International Classification of Headache Disorders, 3rd edition (ICHD-III) established by the International Headache Society in 2018, including chronic migraine, chronic tension-type headache, new daily persistent headache, and hemicrania continua; (2) Conform to the syndrome differentiation standard for headache with liver qi stagnation and phlegm-blood stasis obstructing the collaterals; (3) Aged between 18 and 65 years; (4) Normal communication ability, comprehension capacity, and conscious state; (5) The patient and their family members have been informed and provided consent, and have signed the informed consent form.
Exclusion criteria
Exclusion criteria: Patients meeting any of the following criteria will be excluded from the trial: (1) Those with secondary chronic headache caused by other etiologies; (2) Those with a history of allergy to the investigational drugs or contraindications to high-frequency or low-frequency rTMS therapy; (3) Those who have taken antidepressants, anti-anxiety medications, or other psychotropic drugs within the recent 2 weeks; (4) Those complicated with malignant tumors, hematological system diseases, functional impairment of vital organs, or major mental disorders; (5) Women who are pregnant, lactating, or planning to become pregnant within the next 3 months; (6) Those with traumatic brain injury or focal neurological deficits; (7) Those who have participated in other clinical trials within 3 months prior to this study, or are deemed by the investigators as unsuitable for participation for other reasons; (8) Those with incomplete data (e.g., general information including family history, personal history, past medical history, medication history, etc.); (9) Those who refuse to undergo examinations related to this study; (10) Other circumstances deemed by the investigators as unsuitable for participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of Headache Attacks;Headache Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Headache Associated Symptom Score;TCM score;Dependence on analgesics; | — |
Countries
China
Contacts
Public ContactBin Xu
Xinhua Hospital of Zhejiang Province
Outcome results
None listed