Acute Heart Failure
Conditions
Interventions
Control Group:Xinhuosu + Standard treatment
Treatment group:Xinhuosu + Standard treatment + Shenfu injection
Sponsors
First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 85 years old; 2. Confirmed patients with wet-cold type AHF, and cardiac function classification (NYHA classification) of Class III to IV; 3. The individual or their legal guardian has signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Significantly increased risk of hypotension (persistent systolic blood pressure <90 mmHg); 2. Presence of significant valvular stenosis, hypertrophic or restrictive cardiomyopathy, constrictive pericarditis, or cardiac tamponade; 3. Severe hepatic or renal dysfunction, Child-Pugh class C, or creatinine clearance <30 ml/min; 4. Pregnancy, lactation, or plans to conceive within the next 3 months; 5. Suspected allergy to the investigational product or its components; 6. Patients who have participated in other clinical studies within the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NT-proBNP; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean Arterial Pressure;Stroke volume;Cardiac Index;Arterial blood lactate;Left ventricular end-diastolic diameter;Left ventricular end-systolic diameter;Left ventricular ejection fraction;New York Heart Association (NYHA) Classification;Time to relief of dyspnea symptoms;Cumulative Fluid Balance;C-reactive protein;Interleukin-6;Tumor Necrosis Factor-alpha;Traditional Chinese Medicine Syndrome Score; | — |
Countries
China
Contacts
Public ContactXiao Lu
First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine
Outcome results
None listed