Parkinson's Disease
Conditions
Interventions
Acupuncture Group:Acupuncture therapy was administered while maintaining the patients effective anti-Parkinsonian medication regimen at the original dosage. Acupoint prescription: Sishenzhen (EX-HN1),
Waitlist Group:The patients effective anti-Parkinsonian medication regimen was maintained at the original dosage without alteration. Upon completion of the observation period, the same acupuncture the
Sponsors
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
45 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1)Aged between 45 and 80 years, both male and female. 2)Diagnosed with idiopathic Parkinson's disease according to the Chinese Diagnostic Criteria for Parkinson's Disease (2016). 3)With a Hoehn and Yahr stage of 1 to 3. 4)Having received continuous anti-Parkinsonian medication for at least six months, with a stable dosage for at least one month prior to the study. 5)Capable of understanding and voluntarily signing the informed consent form.
Exclusion criteria
Exclusion criteria: 1)Presence of severe cognitive impairment or hallucinations, rendering the patient unable to cooperate with scale assessments. 2)Participation in any other clinical trials (involving pharmaceuticals, acupuncture, etc.) within one month prior to enrollment in this study. 3)A confirmed diagnosis of severe systemic diseases, such as those affecting the immune system, endocrine system (e.g., pheochromocytoma, hyperthyroidism), respiratory system, cardiovascular and cerebrovascular systems, or hepatic/renal insufficiency. 4)Inability to adhere to a regular regimen of anti-Parkinsonian drugs due to adverse effects or other reasons. 5)Patients with a history of, or planning to undergo, Deep Brain Stimulation therapy or Levodopa Carbidopa Intestinal Gel infusion during the study period. 6)Females who are pregnant or lactating. 7)Subjects planning to have children. 8)History of substance abuse (e.g., alcohol, drugs, caffeine) within the past six months. 9)A documented history of psychiatric disorders or presence of psychotic symptoms. 10)Fear of acupuncture (needle phobia).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Unified Parkinson's Disease Rating Scale(UPDRS); | — |
Secondary
| Measure | Time frame |
|---|---|
| PD sleep scale-2(PDSS-2);Serum Untargeted Metabolomics Analysis;Fecal Untargeted Metabolomics Analysis;Gut Microbiota Metagenomic Sequencing; | — |
Countries
China
Contacts
Public ContactZhuanglixing
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Outcome results
None listed