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Screening of ATM and NBS1 (Nibrin) gene mutations and their effects on sperm DNA damage and chromatin condensation in idiopathic oligospermic infertile men

Investigating the Role of NBN Gene Mutations in Sperm DNA Fragmentation Among Oligozoospermic Men

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ITMCTR
Registry ID
ITMCTR2025002409
Enrollment
Unknown
Registered
2025-12-10
Start date
2023-06-20
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Idiopathic oligospermic male infertility

Interventions

Group 1 (Case group): Blood and semen samples were collected from infertile men for genetic and sperm DNA fragmentation analysi:This is an observational study. No therapeutic intervention or medicatio
Group 2 (Control group): Blood and semen samples were collected from fertile men as controls.:This is an observational study. No therapeutic intervention or medication is administered. Participants on

Sponsors

Dicle University Scientific Research Projects (DÜBAP) Commission under Project No. TIP.23.020.
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: Men diagnosed with idiopathic oligospermia, aged 20–45 years, who provide written informed consent

Exclusion criteria

Exclusion criteria: Men with known genetic syndromes, varicocele, history of chemotherapy or radiotherapy, or chronic systemic diseases

Design outcomes

Primary

MeasureTime frame
Comparison of Semen Parameters and DNA Fragmentation Between Groups;Comparison of Semen Parameters and DNA Fragmentation Between Groups;Genetic analysis:for Group 1;Genetic analysis:for Group 2;

Countries

Turkey

Contacts

Public ContactMahmut Balkan

Dicle University, Faculty of Medicine, Department of Medical Genetics

balkanmah@gmail.com+90 554 821 85 21

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026