Skip to content

Clinical and Mechanistic Study on Berberine's Improvement of Ovulation in Polycystic Ovary Syndrome Based on Chronic Low-Grade Inflammatory State

Clinical and Mechanistic Study on Berberine's Improvement of Ovulation in Polycystic Ovary Syndrome Based on Chronic Low-Grade Inflammatory State

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2025002403
Enrollment
Unknown
Registered
2025-12-06
Start date
2025-10-21
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic Ovary Syndrome

Interventions

control group:Berberine placebo
Treatment group:Berberine

Sponsors

Dongzhimen Hospital of BeijingUniversity of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Individuals with polycystic ovary syndrome: 1) Aged 20–40 years with a desire to conceive; 2) Meeting the Rotterdam criteria established in May 2003 by the European Society of Human Reproduction and Embryology and the American Society for Reproductive Medicine (ESHRE/ASRM); 3) Voluntarily participating in this clinical study and signing an informed consent form. Healthy participants: 1) Aged 20–40 years with a desire to conceive; 2) Regular menstrual cycles within the past year; 3) No significant abnormalities detected by ultrasound; 4) Voluntary participation in this clinical study with signed informed consent.

Exclusion criteria

Exclusion criteria: 1) Conditions exhibiting clinical and endocrine manifestations similar to PCOS, such as thyroid dysfunction, premature ovarian failure, hyperprolactinemia, congenital adrenal hyperplasia, androgen-secreting tumours, or Cushing's syndrome; 2) Patients with concomitant malignancies, severe cardiovascular, hepatic, renal, or haematopoietic disorders, or psychiatric conditions; 3) Presence of other infertility factors, such as genital malformations; 4) Recent use of hormonal medications within the past three months; 5) Individuals with sexually transmitted infections or inflammatory conditions of the genitourinary system; 6) Pregnant individuals; 7) Concurrent participation in other clinical studies that may compromise the integrity of this investigation.

Design outcomes

Primary

MeasureTime frame
Ovulation rate;

Secondary

MeasureTime frame
Inflammation is related;Lymphocyte subsets;Reproductive endocrine indicators;Endometrial receptivity;Menstruation;Intestinal microflora;

Countries

CHINA

Contacts

Public ContactXIAQING

Dongzhimen Hospital of BeijingUniversity of Chinese Medicine

j1995y@126.com18745111436

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026