unstable angina pectoris
Conditions
Interventions
treatment group:Chinese herbal ointment massage + Guideline-directed medical therapy
control group:Vaseline ointment for massage + Guideline-directed medical therapy
Sponsors
Xiyuan Hospital, China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Meets diagnostic criteria for unstable angina pectoris; (2) Meets Traditional Chinese Medicine diagnostic criteria for cold stagnation and blood stasis syndrome; (3) CCS angina pectoris grade I–III; (4) Angina attacks occurring =2 times per week and =6 times per day; (5) Age 18–75 years, irrespective of gender; (6) Sign the informed consent form and voluntarily participate in this study.
Exclusion criteria
Exclusion criteria: (1) Patients with severe congestive heart failure, uncontrolled hypertension grade 3 or higher, cardiomyopathy, severe valvular heart disease, malignant arrhythmias (such as rapid atrial fibrillation, atrial flutter, ventricular tachycardia, second-degree type II or third-degree atrioventricular block), or those with implanted pacemakers; (2) Chest tightness or pain caused by other systemic diseases such as severe cardiovascular neurosis, menopausal syndrome, or cervical spondylosis; (3) Patients with infectious diseases or acute contagious conditions; (4) Those with concurrent acute cerebrovascular disease, malignant tumors, or severe underlying liver/kidney disorders (ALT, AST = 3 times upper limit of normal; serum creatinine > 220 µmol/L in males, > 175 µmol/L in females) or hematopoietic system disorders; (5) Patients with severe skin lesions or dermatological conditions at the ointment application site, including infection, breaks, ulcers, or scars; (6) Patients with bleeding tendencies (e.g., hemophilia, allergic purpura); (7) Patients immediately following strenuous exercise, extreme fatigue, heavy meals, intoxication, or in a state of hunger; (8) Patients with allergy to medications or components used in the study, such as Vaseline and Huoxue Huayu Ointment; (9) Patients who have taken traditional Chinese medicine or Chinese patent medicine within 2 weeks prior to the trial; (10) Pregnant or lactating women; (11) Patients with cognitive impairment unable to undergo corresponding assessments; (12) Patients currently enrolled in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in Angina Symptoms; | — |
Secondary
| Measure | Time frame |
|---|---|
| ECG improvement efficacy rate;Efficacy of Traditional Chinese Medicine Syndrome Score;Seattle angina questionnaire;PHQ-9;GAD-7;Cardiovascular Composite Endpoint Events;hsCRP;IL-6;Platelet activation index; | — |
Countries
china
Contacts
Public ContactJuan Tan
Xiyuan Hospital, China Academy of Chinese Medical Sciences
Outcome results
None listed