Postoperative delirium
Conditions
Interventions
Dexmedetomidine Group:Nebulized inhalation of dexmedetomidine before anesthesia induction
dexmedetomidine combinded with press needles group:Nebulized inhalation of dexmedetomidine before anesthesia induction
Press needles were applyed to bilateral Sanyinjiao, Yanglingquan, and Taichong points before surgery and retained for 3 days postoperatively
Sponsors
The Second Hospital of Huai'an
Eligibility
Sex/Gender
All
Age
65 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1) Patients undergoing orthopedic surgery under general anesthesia; 2) ASA levels I-III; 3) Aged over 65 years old; 4) No history of allergy to dexmedetomidine;5) BMI between 18.5 and 23 kg/m².
Exclusion criteria
Exclusion criteria: 1) Patients who refuse to sign the informed consent form; 2) Patients with severe diseases of vital organs such as the heart, brain, lungs, liver, or kidneys; 3) Patients with psychiatric disorders or a history of long-term anesthetic drug use; 4) Patients with local infection at the acupoint or needle phobia; 5) Patients where acupoint exposure is difficult.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The CAM Scale;Memory Disorder Assessment Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pittsburgh Sleep Quality Index;Quality of Recovery-40 Scale;Blood gas analysis indicators;Visual Analog Score for Pain;Ramsay Scale;Perioperative Blood Pressure and Heart Rate;Surgery duration, anesthesia duration, recovery time, extubation time, and PACU stay duration;Intraoperative remifentanil dosage, postoperative additional analgesic and antiemetic drugs and dosage;Incidence of related adverse reactions within 48 hours after surgery;C-reactive protein and S100 ß concentration in blood; | — |
Countries
China
Contacts
Public ContactHaikou Yang
The Second Hospital of Huai'an
Outcome results
None listed