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Based on the idea of "staged acupuncture" to explore the dose-effect relationship between different acupuncture stimulation amounts and peripheral facial paralysis and the mechanism of action by regulating TLR2/NF-?B signaling pathway

Based on the idea of "staged acupuncture" to explore the dose-effect relationship between different acupuncture stimulation amounts and peripheral facial paralysis and the mechanism of action by regulating TLR2/NF-?B signaling pathway

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2025002360
Enrollment
Unknown
Registered
2025-11-28
Start date
2025-12-01
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peripheral facial paralysis

Interventions

light stimulation group:The acute facial acupoints were treated with needle pressing, and the subacute and convalescent stages were treated with ordinary acupuncture.
medium stimulation group:The acute phase was treated with needle pressing and the subacute phase was treated with ordinary acupuncture, and the operation method was consistent with the light stimulati
Re-stimulation group A:The acute phase was treated with needle pressing, and the recovery phase was treated with ordinary acupuncture and electroacupuncture, and the operation method was consistent wi
Re-stimulation group B:The acute phase was treated with ordinary acupuncture until the end of the acute phase. The subacute and convalescent stages were treated with electroacupuncture.

Sponsors

Quanzhou First Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: (1) Patients who meet the diagnostic criteria for idiopathic facial paralysis (facial paralysis); (2) Patients with a course of disease <7 days and no relevant diagnosis and treatment in the external hospital; (3) Aged between 18 and 70 years old, gender is not limited; (4) The patient is the first unilateral onset; (5) The patient agrees to accept and sign the informed consent form to participate in this study.

Exclusion criteria

Exclusion criteria: (1) Peripheral facial paralysis caused by other factors: hunt syndrome, infection, intracranial diseases, tumors, trauma, otogenic diseases; (2) complicated with diabetes, cardiovascular and cerebrovascular diseases, lung, liver, kidney and hematopoietic diseases and malignant tumors; (3) subjects with a history of severe psychological disorders and mental illness; (4) subjects participating in other clinical trials; (5) Subjects who do not recognize acupuncture treatment

Design outcomes

Primary

MeasureTime frame
House-Brackmann(H-B) Rating Scale, Symptom Rating Scale;

Secondary

MeasureTime frame
efficient;facial nerve electromyography;Facial Disability Index (FDI) Scale;

Countries

China

Contacts

Public ContactXu Ruixu

Quanzhou First Hospital

1032548299@qq.com15880447438

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026