Sepsis
Conditions
Interventions
Sponsors
Longhua Hospital Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Meet Sepsis-3 diagnostic criteria: 1)Infection; 2) Life-threatening organ dysfunction (SOFA score =2); 2. Lower respiratory tract infection; 3. Age =18 years; 4. SOFA score 2-14; 5. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Time since sepsis diagnosis exceeds 48 hours; 2. Pregnant or lactating women; 3. Severe primary diseases affecting survival (e.g., uncontrolled metastatic malignancies, hematologic diseases, HIV); 4. Continuous use of immunosuppressants within 6 months or organ transplant recipients; 5. Participation in other clinical trials within 30 days; 6. APACHE II =30; 7. Known allergy to herbal components in the study drug.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Day 14 Sequential Organ Failure Assessment Score Improvement Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| SOFA Score Improvement by TCM Syndrome Type;TCM Symptom Score Improvement;28-Day All-Cause Mortality;APACHE II Score;DIC Score;Mechanical Ventilation Duration;ICU Length of Stay;Hospitalization Duration;SOFA Score Improvement Over Time (Day 3, 5, 7, 14); | — |
Countries
China
Contacts
Public ContactFang Bangjiang
Longhua Hospital Shanghai University of Traditional Chinese Medicine
Outcome results
None listed