Precocious puberty in children
Conditions
Interventions
Isolated premature breast development non-exposed group:Do not use the Great Yin Tonic Pill.
Group exposed to isolated early breast development:Use the Great Yin Tonic Pill
Idiopathic central precocious puberty non-exposed group:Do not use Dabu Yinwan or similar traditional Chinese medicines, but Western medical treatments can be used
Idiopathic central precocious puberty exposure group:You can use Western medicine if you use Da Bu Yin Wan but do not use similar traditional Chinese patent medicines
Sponsors
Children's Hospital of Fudan University
Eligibility
Sex/Gender
All
Age
No minimum to 10 Years
Inclusion criteria
Inclusion criteria: According to the classification of precocious puberty and the characteristics of clinical treatment the target population of this study was "simple precocious breast development" in partial precocious puberty and "idiopathic central precocious puberty" in central precocious puberty. The main syndrome types of traditional Chinese medicine are all yin deficiency and fire prosperity syndrome.
Exclusion criteria
Exclusion criteria: Confirmed by the judgement of the study physician.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone;Hormones six;Ovarian volume;Testicular volume;Nipple diameter;Cranial MRI;Blood routine;Urinalysis;Routine;Liver and kidney function;Electrocardiogram;Uterine length;Breast staging; | — |
Countries
China
Contacts
Public Contactyujian
Children's Hospital of Fudan University
Outcome results
None listed