Post-COVID-19 Condition
Conditions
Interventions
Sponsors
Chengdu University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion Criteria for PCC Patients People who meet all of the following criteria will be included: (1) age 18-65 years, (2) fulfilling WHO criteria for PCC(A history of confirmed SARS-CoV-2 infection, and symptoms occur during the initial illness or after initial recovery from an acute COVID-19 episode lasting for at least 2 months at 3 months from the infection onset, and the symptoms cannot be explained by an alternative diagnosis.), (3) having subjective cognitive problems, (4) native Chinese speakers, (5) right handedness, (6) voluntary to participate in the study and signing the informed consent form. 2. Inclusion Criteria for Healthy Controls People who fulfil all of following criteria will be included: (1) age 18-65 years, (2) a confirmed COVID-19 history through RT-PCR testing of a nasal/pharyngeal swab, without residual symptoms after recovery from the acute phase of COVID-19, (3) native Chinese speaker, (4) right handedness, (5) voluntary to participate in the study and signing the informed consent form.
Exclusion criteria
Exclusion criteria: Exclusion criteria for PCC Patients and Healthy Controls Those who have any of following conditions will be excluded: (1) preexisting cognitive symptoms before COVID-19; (2) previous or current diagnosis of neurological or neuropsychiatric disorders, such as delirium, Alzheimer's disease, frontal-temporal lobe degeneration, Lewy body dementia, cerebrovascular disease, prion disease, Parkinson's disease, Huntington's disease, multiple sclerosis, brain tumor, hydrocephalus, subdural hematoma, traumatic brain injury and neurodevelopmental disorders, schizophrenia, bipolar disorder, severe depression disorder, severe anxiety disorder, obsessive-compulsive disorder, post-traumatic stress disorder, dissociative disorder, eating disorder, severe sleep-wake disorder, alcoholism or substance addiction, personality disorder, etc.; (3) previous or current diagnosis of diseases or conditions that may affect cognitive performances, such as hypothyroidism, hypoglycemia, hypercalcemia, thiamine deficiency, niacin deficiency, HIV infection, neurosyphilis, cryptococcal infection, temporal arteritis, systemic lupus erythematosus, Cushing's syndrome, adrenal leukodystrophy, metachromatic leukodystrophy, etc.; (4) current diagnosis of severe cardiovascular, liver, kidney and blood diseases, such as heart failure, liver and kidney failure, severe anemia, etc.; (5) prior loss of consciousness; (6) history of major surgery within a year; (7) long-term use of drugs that may influence cognition, such as tranquilizers, somnifacients, melatonin, and antidepressants, antipsychotic drugs, etc.; (8) long-term use of glucocorticoids, immunosuppressants; (9)previous acupuncture or moxibustion treatment within 3 months; (10) involvement of other clinical study within 4 weeks; (11) obesity(BMI=28); (12) severe hearing dysfunction; (13) severe visual dysfunction or color blindness; (14) severe limb dysfunction; (15) metal or electronic material implantation, or claustrophobia; (16) pregnancy, lactation, or within 1 year postpartum.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The total score of Addenbrooke's Cognitive Examination III(ACE-III); | — |
Secondary
| Measure | Time frame |
|---|---|
| Total score of Fatigue Serverity Scale(FSS);Total score of 17-item Hamilton Depression Scale(HAMD-17);Total score of Generalized Anxiety Disorde-7 (GAD-7);The subscores of the MOS item short from health survey(SF-36);The sequences of Digit Span Forward Test(DST-F);The correct responses of Symbol Digit Modality Test(SDMT);The learning, delayed recall of Auditory Verbal learning Test (AVLT);The learning, delayed recall of Rey Auditory Verbal learning(RAVLT);The time of Trail Making Test part A (TMT-A);The time of Trail Making Test part B (TMT-B);Times of Stroop Color Word Test (SCWT);The correct words of Controlled Oral Association Word Test;Correct responses of Boston Naming Test (BNT);The accuracies of copy, immediate recall and delayed recall of Rey-Osterrieth Complex Figure Test(RCFT);The sequences of digit span backward test(DST-B); | — |
Countries
China
Contacts
Public ContactXi Wu
Chengdu University of Traditional Chinese Medicine
Outcome results
None listed