Mild Cognitive Impairment and Self-Perceived Cognitive Decline
Conditions
Interventions
Mild Cognitive Impairment Electroacupuncture Group (MCI Electroacupuncture Group):Electroacupuncture
Self-perceived cognitive decline electroacupuncture group (SCD electroacupuncture group):Electroacupuncture
Mild Cognitive Impairment Sham Group (MCI Sham Group):sham acupuncture
Placebo group for self-perceived cognitive decline (SCD placebo group):sham acupuncture
Healthy individuals in the electroacupuncture group (healthy control group):Electroacupuncture
Sponsors
Guangdong Provincial Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Inclusion Criteria for Participants with Mild Cognitive Impairment (MCI) Meet the diagnostic criteria for MCI established by the International Working Group: 1. The patient and/or their informed caregiver (e.g., family member, caregiver) reports a persistent decline in cognitive function; 2. One or more cognitive impairments are confirmed through standardized neuropsychological tests (e.g., memory, attention, language, executive function, visuospatial abilities); 3. The patient's instrumental activities of daily living (IADLs) remain largely intact, and basic activities of daily living (ADLs) (e.g., dressing, bathing, eating, toileting, walking) are typically preserved; 4. The degree and scope of cognitive impairment are insufficient to significantly interfere with the patient's independent living (especially ADLs), and do not meet the diagnostic criteria for dementia; 2) Age between 40-75 years, male or female; 3) Physically intact limbs, no motor dysfunction, and no central nervous system diseases; 4) Mini-Mental State Examination (MMSE) score ranges from 18 to 26 (inclusive); 5) Right-handed; 6) Voluntarily signed the informed consent form. (2) Inclusion Criteria for Participants with Self-Reported Cognitive Decline 1) Meet the diagnostic criteria of the Self-Reported Cognitive Decline Initiative (SCD-i) Working Group: 1. The patient has experienced a persistent (usually =6 months) decline in cognitive abilities (especially episodic memory) compared to their past level; 2. Comprehensive neuropsychological testing (assessing memory, language, attention, executive function, visuospatial abilities, etc.) shows that all cognitive domain scores fall within the normal reference range for age, sex, and education level; 3. The patient expresses significant concern or distress regarding the cognitive decline; 2) Age between 40-75 years, male or female; 3) Physically intact limbs, no motor dysfunction, and no central nervous system diseases; 4) MMSE score ranges from 26 to 30 (inclusive); 5) Subjective Cognitive Decline Questionnaire 9 (SCD-Q9) score =5; 6) Right-handed; 7) Voluntarily signed the informed consent form. (3) Inclusion Criteria for Healthy Participants 1) Age between 18-35 years, male or female; 2) Physically intact limbs, no motor dysfunction, and no central nervous system diseases; 3) MMSE =27; 4) Right-handed; 5) Voluntarily signed the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Exclusion Criteria for Mild Cognitive Impairment Participants 1)Participants with a history of brain-related diseases that affect cognitive function; 2) Participants who experience sudden illnesses during the experiment that may impact the results; 3) Participants who are unable to cooperate and complete the experiment; 4) Participants with severe mental disorders; 5) Participants with a history of epilepsy; 6) Pregnant women; 7) Participants with skin diseases or injuries at the treatment site. (2) Exclusion Criteria for Self-Reported Cognitive Decline Participants 1) Participants with a history of brain-related diseases that affect cognitive function; 2) Participants who experience sudden illnesses during the experiment that may impact the results; 3) Participants who are unable to cooperate and complete the experiment; 4) Participants with severe mental disorders; 5) Participants with a history of epilepsy; 6) Pregnant women; 7) Participants with skin diseases or injuries at the treatment site. (3) Exclusion Criteria for Healthy Participants 1) Participants with a history of brain-related diseases that affect cognitive function; 2) Participants who experience sudden illnesses during the experiment that may impact the results; 3) Participants who are unable to cooperate and complete the experiment; 4) Participants with severe mental disorders; 5) Participants with a history of epilepsy; 6) Pregnant women; 7) Participants with skin diseases or injuries at the treatment site.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain Functional Connectivity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment (MoCA);Digit Span Test;Verbal Fluency Test;Trail Making Test; | — |
Countries
China
Contacts
Public ContactHaining Ou
Guangdong Provincial Hospital of Traditional Chinese Medicine
Outcome results
None listed