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The impact of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Postoperative Delirium (POD) in elderly patients with Non-acute fragile brain function (NFBF): A prospective, randomized, controlled study

The impact of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Postoperative Delirium (POD) in elderly patients with Non-acute fragile brain function (NFBF): A prospective, randomized, controlled study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2025002263
Enrollment
Unknown
Registered
2025-11-21
Start date
2025-12-01
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative delirium

Interventions

Transcutaneous auricular vagus nerve stimulation group:Electrical stimulation was given in the distribution area of the concha vagus nerve
Control group (tnVNS group):Stimulation at scapha region (clavicle/shoulder points, non-vagus nerve area). Same parameters as taVNS group

Sponsors

Beijing Friendship Hospital, Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1) Age 60-85 years, non-acute fragile brain function diagnosis, any gender; 2) Patients undergoing general anesthesia with endotracheal intubation for laparoscopic abdominal tumor resection (gastric/colorectal); 3) BMI 18-30 kg/m²; 4) ASA class I-III; 5) Voluntary participation with informed consent.

Exclusion criteria

Exclusion criteria: 1) Local skin infection/injury in auricular concha area; 2) Illiteracy or severe visual/hearing impairment; 3) History of psychotropic drug abuse; 4) Preoperative chronic pain with central analgesics use, opioid dependence; 5) Severe hepatic/renal dysfunction; 6) Pacemaker implantation or cardiac conduction disorders.

Design outcomes

Primary

MeasureTime frame
Incidence of postoperative delirium;—

Secondary

MeasureTime frame
Delirium severity grading;Acetylcholinesterase (AChE);Interleukin-6 (IL-6);Tumor necrosis factor-a (TNF-a);Postoperative delayed cognitive dysfunction;Pain score;Gastrointestinal recovery;Intraoperative anesthesia related parameters;Health economic indicators;Monitoring of perioperative complications and severe events during postoperative hospital stay;—

Countries

China

Contacts

Public ContactLi-xin An

Beijing Friendship Hospital, Capital Medical University

anlixin8120@163.com13810248120

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Apr 30, 2026