Refractory Peripheral Ophthalmoplegia
Conditions
Interventions
Control Group:Periocular injection
Sponsors
Beijing Friendship Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosis of Peripheral Ophthalmoplegia by an ophthalmologist. 2. Aged 18 to 80 years, inclusive. 3. Symptoms refractory to conventional therapy (e.g., oral vitamins, hormones, vasodilators, or injections) for over 1 month. 4. Mentally competent, cooperative, and with stable vital signs. 5. Willing to provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. Congenital Ophthalmoplegia, Chronic Progressive Ophthalmoplegia, central ophthalmoplegia, or painful ophthalmoplegia; history of extraocular muscle surgery. 2. Etiology due to intracranial/orbital mass or Myasthenia Gravis. 3. Any clinically significant untreated or unstable condition identified prior to screening. 4. Previous neurosurgical intervention or unresolved head trauma. 5. Contraindications to acupuncture (e.g., bleeding tendency, coagulopathy, local skin infection/ulceration/scarring). 6. Inability to complete synoptophore examination due to nystagmus or abnormal retinal correspondence. 7. History of allergic reaction to mecobalamin, Ginkgo biloba tablets, or Compound Anisodine Hydrobromide Injection. 8. Contraindications to MRI (e.g., metallic implants, claustrophobia). 9. Inability to cooperate with study procedures or complete the treatment course. 10. Pregnancy, lactation, or women of childbearing potential not using contraception. 11. Concurrent participation in another clinical trial. 12. Any other condition deemed by the researcher to compromise subject safety or study validity.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The maximum degree of the nine positions on the Synoptophore.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Synoptophore Grade I Visual Function;Synoptophore Fusion Range;Synoptophore Stereoscopic Vision;Berke Muscle Strength Evaluation Method;pupil size;Diplopia Symptom Rating Scale;Patient Health Questionnaire-9 items, PHQ-9;Generalized Anxiety Disorder-7, GAD-7; | — |
Countries
China
Contacts
Public ContactHongyang Li
Beijing Friendship Hospital, Capital Medical University
Outcome results
None listed