Skip to content

The mechanism of Zishen Jiangu Formula in regulating the Nrf2/SLC7A11/GPX4 axis to inhibit ferroptosis and prevent type 2 diabetic osteoporosis

The mechanism of Zishen Jiangu Formula in regulating the Nrf2/SLC7A11/GPX4 axis to inhibit ferroptosis and prevent type 2 diabetic osteoporosis

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ITMCTR
Registry ID
ITMCTR2025002217
Enrollment
Unknown
Registered
2025-11-17
Start date
2025-02-28
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetic osteoporosis

Interventions

Type 2 diabetic osteoporosis group:none
control group:none

Sponsors

Shenzhen Guangming District People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
45 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Diagnostic criteria for type 2 diabetes: Refer to the diagnostic criteria in the "Chinese Guidelines for the Prevention and Treatment of Type 2 Diabetes (2020 Edition)" : Presence of diabetic symptoms such as "three more and one less" plus random blood glucose =11.1 mmol/L; Or fasting plasma glucose (FPG) = 7.0mmol/L or 2-hour postprandial blood glucose (2hPG) of the glucose tolerance test (OGTT) = 11.1 mmol/L; Or glycated hemoglobin (HbA1c) = 6.5%. 2.Diagnostic criteria for type 2 diabetes mellitus complicated with osteoporosis: Refer to the diagnostic criteria in the "Diagnosis and Treatment Guidelines for Primary Osteoporosis (2017)" : Meet the diagnostic criteria for type 2 diabetes mellitus mentioned in 1) above; At the same time the bone mineral density T value is =-2.5 or brittle fractures have occurred before calcium supplements or other drugs for treating osteoporosis are effective or the diagnosis has been confirmed by imaging examination.

Exclusion criteria

Exclusion criteria: 1.Patients with diseases related to the heart lungs liver kidneys thyroid gland etc. as well as those with connective tissue diseases gynecological diseases digestive system diseases fibroosteitis osteomalacia and severe cardiovascular and cerebrovascular diseases; 2. Failure to follow visitors on time; 3. Patients who have taken sex hormones adrenal cortical hormones and other drugs that affect bone metabolism within half a year; 4. Those with bad habits such as excessive drinking.

Design outcomes

Primary

MeasureTime frame
Ferroptosis index;

Secondary

MeasureTime frame
ELISA;

Countries

China

Contacts

Public ContactLi Chenxing

Shenzhen Guangming District People's Hospital

chansealmy@126.com15017576241

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026