Sepsis
Conditions
Interventions
Experimental group:Ma Huang Fu Zi Xi Xin Decoction formula with modifications, 100ml, once daily.
Control Group:100ml of warm water plus 0.001% quinine once daily.
Sponsors
Jiangsu Province Hospital of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Conform to thediagnosis criteria for sepsis and the TCM Shaoyin cold transformation syndrome criteria. 2. Age between 18-90 years old, gender. 3. Expected ICU stay7 days. 4. Informed consent, voluntary participation. The process of obtaining the informed consent signed by the patient's legal representative should comply with GCP regulations.
Exclusion criteria
Exclusion criteria: 1. Currently participating in or having participated in other clinical trials within the past month. 2. Pregnancy or lactation. 3. Individuals with skin damage or infection at the examination site, making ultrasound examination impossible. 4. Patients with renal failure on long-term dialysis. 5. Patients with disseminated tumors or undergoing chemotherapy and other special treatments. 6. Unstable angina / acute myocardial infarction, heart rate <50 beats per minute, second-degree or higher atrioventricular block. 7. Patients with gastrointestinal dysfunction who cannot receive Chinese medicine via the gastrointestinal tract. 8. Patients allergic to Chinese medicine or unable to tolerate it.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The ratio of the difference in partial pressure of carbon dioxide (PaCO2) between central venous and arterial blood to the difference in oxygen content between arterial and central venous blood.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Left ventricular ejection fraction;Serum lactate;Serum Nitric Oxide;Serum inducible nitric oxide synthase content;Serum endothelial nitric oxide synthase content;Left Ventricular Short-Axis Shortening Fraction;Mitral annulus systolic peak velocity;Left Ventricular Segmental Qualitative Analysis;The motion velocity of the lateral wall and septum of the mitral annulus.;Middle Cerebral Artery Perfusion Index;Internal Carotid Artery Perfusion Index;Renal interlobar artery perfusion index;Superior Mesenteric Artery Perfusion Index;Portal Vein Perfusion Index;Hepatic Artery Perfusion Index; | — |
Countries
China
Contacts
Public ContactLu Jun
Jiangsu Province Hospital of Chinese Medicine
Outcome results
None listed