chemotherapy-induced peripheral neuropathy
Conditions
Interventions
2. Fake electroacupuncture group :The sham electroacupuncture group opened 1 inch horizontally to the radial side at the acupoints of Waiguan, Quchi, Fenglong, Hegu, and Yanglingquan on both sides
The midpoint of the horizontal line connecting the bilateral Sanyin intersection and Achilles tendon. Use a 1.5-inch microneedle to lightly pierce the skin without detachment, without manual operation
3. Tongluo Fujin (TLFJ) group:The TLFJ group received the Tongluo Fujin acupuncture method, with the main acupoints selected as Waiguan, Quchi, Hegu, Yanglingquan, Fenglong, and Sanyinjiao. Using a 1.
1. Western medicine group :The Western medicine group was given oral methylcobalamin tablets three times a day 0.5 mg each time with a 7-day cycle for two consecutive cycles
Sponsors
First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Patients diagnosed with multiple myeloma, breast cancer, or colorectal cancer (regardless of type and stage); Have received at least one course of treatment with bortezomib, albumin-bound paclitaxel, or oxaliplatin; Diagnosed with PN within 6 months, presenting with numbness, reduced sensation, pain, or sensory abnormalities in the extremities; some patients may experience muscle spasms, muscle weakness, myalgia, or even paralysis; Aged over 18 years, with an expected survival period of more than 3 months; Karnofsky Performance Status (KPS) score = 60; Voluntarily agree to participate in this study, willing to undergo acupuncture treatment, and able to sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with pre-existing neurological, musculoskeletal disorders, peripheral sensory abnormalities in diabetic patients, poisoning, infection, radiotherapy, or other causes of peripheral neuropathy, as well as those undergoing treatment with other drugs that may cause neurotoxicity; 2. Patients with infections or other lesions at the acupuncture site that make acupuncture therapy inadvisable; 3. Patients with platelet count (PLT) < 30×109/L prior to treatment; 4. Patients with severe cardiovascular diseases, infections, or dysfunction of the liver, kidneys, or other organs, or those with a history of needle fainting; 5. Patients with mental abnormalities, pregnant women, or breastfeeding mothers; 6. Patients currently participating in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Electroencephalogram;Grading of Peripheral Neuropathy;PNQ Rating;FACT-NTX Score;Karnofsky Performance Status;TCM syndrome score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood Routine;Four coagulation tests; | — |
Countries
China
Contacts
Public ContactShi Zhexin
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Outcome results
None listed