Anhedonic Depression
Conditions
Interventions
Fluoxetine group:Fluoxetine Hydrochloride Specifications and Administration: Manufactured by Eli Lilly and Company, USA. Specifications: 20mg*28 capsules. Dosage: 20mg per day. Take it half an hour af
Shuyi SAN + fluoxetine Group:The composition and administration of Shuyi SAN: Morinda officinalis 15g Curculigo orchioides 6g Atractylodes macrocephala 15g Astragalus membranaceus 15g Pinellia ternata
Healthy control group:No intervention
Sponsors
Linyi Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) Age between 18 and 60 years old;2) Right-handed; 3) Meeting the diagnostic criteria of DSM-5 for major depressive disorder with melancholic features and the diagnostic criteria of Traditional Chinese Medicine; 4) Current disease course (last episode) of at least 2 weeks;5) HAMD-24 score=18; Snith-Hamilton Pleasure Scale (SHAPS) score=3; 6) No antidepressant use within the last half month before enrollment; 7) No electroconvulsive therapy within the last half year before enrollment; 8) Head circumference: 52 - 60 cm.Healthy control group: 1) Age ranging from 18 to 60 years old; 2) HAMD-24 score < 8 points SHAPS < 3 points; 3) No severe physical illness no history of mental illness alcohol or drug abuse; 4) Head circumference: 52 - 60 cm.
Exclusion criteria
Exclusion criteria: 1) Coexisting with another mental disorder; 2) History of alcohol or drug dependence or smoking more than 10 cigarettes per day; 3) Severe physical diseases of the heart, liver, kidneys, brain and hematopoietic system, central nervous system infection, head injury, epilepsy, multiple sclerosis, toxic metabolic diseases, Parkinson's disease or intracranial tumors; 4) Family history of hereditary diseases; 5) Endocrine system diseases such as diabetes, hyperthyroidism or hypothyroidism; 6) Pregnant or lactating women or those with photosensitivity. Healthy control group: 1) Those with a family history of mental illness within two generations; 2) Pregnant or lactating women or those with photosensitivity.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Nrf2/glutathione peroxidase 4 in the blood;TCM Syndrome Assessment Scale;Indicators of brain activation and indicators of brain network connectivity; | — |
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale 24-item,HAMD-24;Snaith-Hamilton Pleasure Scale,SHAPS; | — |
Countries
China
Contacts
Public ContactXiaoxi Liu
Linyi Central Hospital
Outcome results
None listed