Irritable Bowel Syndrome with Diarrhea (IBS-D) with Comorbid Depression
Conditions
Interventions
The same-effect acupoints - Group A:Acupuncture was applied to Tianshu and Zusanli
The same-effect acupoints - Group B:Acupuncture was applied to Baihui and Taichong
complementary-effect acupoints:Acupuncture was applied to Baihui and Zusanli
Sham acupuncture group:Non-acupoint shallow needling
Sponsors
Institute of Psychology of the Chinese Academy of Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for IBS-D according to Rome IV, with a Hospital Anxiety and Depression Scale-Depression subscale (HADS-D) score indicating mild to moderate depressive state (8 = HADS-D score = 14). 2. Aged between 18 and 40 years, right-handed, both genders included. 3. Based on a 2-week daily bowel diary, report Bristol Stool Form Scale type 6 or 7 for at least 4 days, and Bristol Stool Form Scale type 1 or 2 for fewer than 4 days; have an average daily abdominal pain score of =3 points in the past week. 4. No history of acupuncture treatment within the past 6 months. 5. Voluntarily participate in this study and provide signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Other IBS subtypes: IBS with constipation (IBS-C), mixed IBS (IBS-M), or unsubtyped IBS (IBS-U). 2. History of organic bowel diseases such as inflammatory bowel disease, microscopic colitis, celiac disease, or Crohn's disease. (Participants with alarm features including unexplained weight loss (=10% weight loss in 3 months), rectal bleeding not from hemorrhoids or anal fissures, nocturnal diarrhea, or family history of colorectal cancer must provide colonoscopy results from within the past 2 years). 3. Use of antidepressants or medications that treat IBS symptoms within 2 weeks prior to treatment, including Chinese herbal medicine or proprietary Chinese medicines, antidiarrheals, antispasmodics, gut antibiotics, probiotics, etc. 4. Secondary depressive disorder due to organic diseases, medications, or psychotic disorders; or previous diagnosis of schizophrenia, bipolar disorder, or other psychiatric disorders. 5. Diabetes, thyroid dysfunction, severe acute/chronic organic diseases, kidney or liver diseases. 6. History of abdominal surgery (patients with appendectomy, hemorrhoid surgery, or polyp surgery performed more than 3 months ago can be included). 7. History of alcohol or substance abuse. 8. Contraindications for MRI examination: patients with cardiac pacemakers, neurostimulators, artificial metallic heart valves; aneurysm clips (except non-ferromagnetic ones such as titanium alloy); intraocular metal fragments, inner ear implants, metal prostheses, metallic joints, or any internal ferromagnetic objects; patients with severe hyperthermia; claustrophobia. 9. Pregnant or lactating women. 10. Patients participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effective response rate of abdominal pain;Effective response rate of depressive symptoms;Resting-state functional magnetic resonance image; | — |
Secondary
| Measure | Time frame |
|---|---|
| IBS symptom severity score;IBS Quality of Life Score;Self-rating anxiety scale;Self-rating depression scale;Patient Health Questionnaire-9;3D T1 structural image;Diffusion tensor imaging;Task-state functional magnetic resonance imaging;intestinal flora; | — |
Countries
China
Contacts
Public ContactYaZhuo Kong
Institute of Psychology of the Chinese Academy of Sciences
Outcome results
None listed