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Evaluation of the therapeutic effect of Transcutaneous Electrical Acupoint Stimulation in alleviating opioid tolerance in patients with Hepatocellular carcinoma cancer pain and label free proteomic study of serum exosomes

Evaluation of the therapeutic effect of TEAS in alleviating opioid tolerance in patients with HCC pain and label free proteomic study of serum exosomes

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2025002162
Enrollment
Unknown
Registered
2025-11-08
Start date
2025-03-26
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatocellular carcinoma

Interventions

Observation group:Basic treatment + Transcutaneous Electrical Acupoint Stimulation
Control group:Basic treatment + placebo Transcutaneous Electrical Acupoint Stimulation

Sponsors

Yueyang Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Patients meeting the diagnostic criteria for Hepatocellular carcinoma; (2) Age =50 and =80 years old gender not limited; (3) The NRS score within 24 hours before screening is =4 points; (4) Patients with Child-Pugh grade A or B; (5) Patients with an expected survival period > 3 months; (6) Clear consciousness capable of assessing one's own pain and quality of life; (7) Those who understand and agree to participate in this study and sign the informed consent form.

Exclusion criteria

Exclusion criteria: (1) Patients with other physical or pathological pains; (2) Patients who have undergone tumor resection within the past 3 to 6 months; (3) Patients with severe complications such as persistent ascites abdominal cavity infection gastrointestinal bleeding liver failure and abdominal cavity hemorrhage; (4) Suffer from severe acute or chronic organic diseases or mental disorders; (5) Patients with contraindications to transcutaneous acupoint electrical stimulation such as those with local skin damage those who are particularly sensitive to electric current those with pacemakers or cardiovascular stents; (6) Patients who have previously received percutaneous electrical acupoint stimulation; (7) Patients who are scheduled to undergo surgery within the last two months. If any of the above conditions is met it will be excluded.

Design outcomes

Primary

MeasureTime frame
Opioid drug tolerance index;

Secondary

MeasureTime frame
The number of breakouts of pain;Proteomics analysis;Assessment of quality of life;Assessment of pain degree;The frequency of gastrointestinal side effects;

Countries

China

Contacts

Public ContactZHU LU

Shanghai acupuncture and moxibustion Meridian Research Institute

601584345@qq.com15951891067

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026