Postpartum Depression
Conditions
Interventions
Healthy control group:No intervention
True Acupuncture Treatment Group:True Acupuncture
Sham Acupuncture Treatment Group:Sham Acupuncture
Sponsors
Shenzhen Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 49 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for patients: (1) met the diagnostic criteria for perinatal depression according to the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-V); (2)aged 20–49 years; right-handed;(3)onset of disease within 12 months postpartum; (4) screened by the Edinburgh Postnatal Depression Scale (EPDS) and diagnosed with moderate depressive disorder based on the 17-item Hamilton Depression Rating Scale (HDRS17) score;(5) voluntary participation in the study with signed written informed consent. Inclusion criteria for healthy subjects:(1)aged 20–49 years;(2)within 1 year after delivery with no obvious complaints of discomfort;(3)Routine physical examination items in the past month (three major routine tests liver and kidney function biochemistry electrocardiogram abdominal B-ultrasound) were within the normal range;(4)The results of various scale assessments are within the normal range;(5)good compliance willingness to cooperate with various studies and signing the informed consent form.
Exclusion criteria
Exclusion criteria: Exclusion criteria for patients:(1) bipolar disorder (based on DSM-V diagnostic criteria) or severe mental disorders such as schizophrenia; (2) inability to comprehend questionnaire content or participate in structured interviews due to brain disorders or intellectual disabilities; (3) pregnancy; (4) a score exceeding 2 on the "suicidality" item of the 17-item Hamilton Depression Rating Scale (HDRS17); (5) having committed suicide within 1 year;(6) having taken psychotropic drugs within 1 month before treatment or received other antidepressant therapies;(7) having metal implants in the body or being unable to cooperate with the examination due to claustrophobia and other conditions. Exclusion criteria for healthy subjects:(1) bipolar disorder or severe mental disorders such as schizophrenia; with a history of depressive disorder;(2) complicated with severe diseases such as hypertension diabetes and coronary heart disease;(3) pregnancy;(4) complicated with severe liver and kidney dysfunction cardio-cerebrovascular diseases hematopoietic system diseases etc.;(5) having committed suicide within 1 year;(6) participating in other clinical studies currently.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 17-item Hamilton Depression Rating Scale (HDRS17); | — |
Secondary
| Measure | Time frame |
|---|---|
| Cerebral Functional Magnetic Resonance Imaging (fMRI) Scan;Electroencephalogram (EEG);Self - Rating Depression Scale(SDS);Self-Rating Anxiety Scale (SAS);Edinburgh Postnatal Depression Scale(EPDS);Pittsburgh Sleep Quality Index(PSQI);Gut microbiota data;Peripheral blood metabolomics;Peripheral blood inflammatory cytokines; | — |
Countries
China
Contacts
Public ContactYumei Zhou
Shenzhen Traditional Chinese Medicine Hospital
Outcome results
None listed