Osteoporosis
Conditions
Interventions
primary osteoporosis group:none
control group:none
Sponsors
Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine
Eligibility
Sex/Gender
All
Age
45 Years to 80 Years
Inclusion criteria
Inclusion criteria: Age Requirement??: =45 years old.??Diagnostic Criteria (based on Dual-Energy X-ray Absorptiometry DXA)??:??OP Group??: Lumbar spine bone mineral density (BMD) T-score = -2.5 (meeting diagnostic criteria for osteoporosis).??Normal Group??: Lumbar spine bone mineral density (BMD) T-score > -1.0 (indicating normal bone density).??Health Status??: Absence of severe cardiac hepatic or renal dysfunction.??Medication and Medical History??: No other diseases affecting bone metabolism (e.g. thyroid disorders diabetes); No recent use of bone metabolism-related medications (e.g. bisphosphonates).
Exclusion criteria
Exclusion criteria: 1)Patients with diseases involving the heart lungs liver kidneys or thyroid ??including?? those with diabetes mellitus rheumatic and connective tissue diseases gynecological diseases digestive system disorders osteitis fibrosa osteomalacia or severe cardiovascular and cerebrovascular diseases;2)Patients who have taken medications affecting bone metabolism (e.g. sex hormones glucocorticoids) within the preceding six months;3)Individuals with substance abuse issues such as alcoholism;4)Cases presenting during the acute phase of fractures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Core pathway indicators (TGF-ß1,COX-2 and PGE2concentration, EP4 activity levels);Osteogenic functional markers (Serum calcium, Phosphorus, ALP, Osterix, RUNX2)?;Bone quality indicators (Bone mineral density (BMD)); | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient baseline data (Age, Sex/Gender, Body Mass Index (BMI), History of Present Illness (HPI), Past Medical History (PMH), Surgical History, Medication History, Blood Pressure (BP), Serum Albumin (ALB), Serum Creatinine (SCr), Blood Lipids, Serum Uric Acid (SUA), Fasting Blood Glucose (FBG), and other general biochemical parameters);Pattern/syndrome of TCM differentiation (Kidney essence deficiency pattern: soreness and weakness of the waist and knees, aversion to cold and cold limbs, dizziness and tinnitus; Liver-kidney yin deficiency pattern: blurred vision, five-center heat/fever, red tongue with scant coating); | — |
Countries
China
Contacts
Public ContactLin Xiaosheng
Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine?
Outcome results
None listed