Atopic dermatitis
Conditions
Interventions
Trial group :Neoliquiritin cream topical application
Control group:Denuded cream topical
Sponsors
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Meets the Williams' diagnostic criteria for atopic dermatitis with mild-to-moderate severity (IGA score: 2-3 or EASI score: 0-21); 2. Aged 18 to 70 years regardless of sex; 3. Capable of understanding the study procedures and having provided written informed consent.
Exclusion criteria
Exclusion criteria: 1. Other active skin diseases that may affect condition assessment such as contact dermatitis; 2. Systemic treatment with biologics or immunosuppressants within 1 month prior to enrollment; 3. Topical treatments within 14 days including calcineurin inhibitors (tacrolimus or pimecrolimus) corticosteroids PDE-4 inhibitors (crisaborole) JAK inhibitors (ruxolitinib) and topical antihistamines; 4. Severe uncontrolled local or systemic acute/chronic infections; 5. Significant systemic diseases (e.g. cardiovascular respiratory digestive neurological endocrine genitourinary diseases); 6. History of malignancy primary or secondary immunodeficiency or hypersensitivity disorders; 7. Major surgery within 8 weeks before enrollment or planned surgery during the study; 8. Pregnancy lactation or women planning pregnancy; 9. History of alcohol abuse drug addiction or substance abuse; 10. History of severe psychiatric disorders (personal or familial); 11. Participation in other clinical trials within 1 month before enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eczema Area and Severity Index score (EASI score); | — |
Secondary
| Measure | Time frame |
|---|---|
| Dermatologic Quality of Life Index (DLQI);Itch Intensity Visual Analogue Scale (VAS);Investigator Global Assessment (IGA); | — |
Countries
China
Contacts
Public ContactXiaojie Ding
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai
Outcome results
None listed