Acute Radiation Dermatitis
Conditions
Interventions
Control Group:Standard Care
Sponsors
Sichuan Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) Age 18-70 years; 2) Locally advanced NPC (staged as III-IVa according to the 8th edition of the American Joint Committee on Cancer/International Union Against Cancer); 3) Completion of 2 to 3 cycles of induction chemotherapy, with planned radical Concurrent Chemoradiotherapy (CCRT); 4) Karnofsky Performance Status (KPS) score = 70; 5) Normal laboratory reference ranges for blood routine, liver function, and kidney function.
Exclusion criteria
Exclusion criteria: 1) Previous history of head and neck radiotherapy; 2) Presence of existing skin diseases in the head and neck radiotherapy area; 3) Concurrent targeted therapy or immunotherapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Radiation Skin Toxicity Score of the Radiation Therapy Oncology Group (RTOG); | — |
Secondary
| Measure | Time frame |
|---|---|
| Lymphocyte Subsets;Quality of Life Score;gut microbiota;skin microbiota;serum inflammatory cytokines (IL-1ß, IL-6, TNF-a);Blood Metabolomics ;Acute Radiation Dermatitis-Related Pain Score;Acute Radiation Dermatitis-Related Itch Score;Short-Term Efficacy of Nasopharyngeal Cancer; | — |
Countries
China
Contacts
Public Contactjun yin
Sichuan Cancer Hospital
Outcome results
None listed