coronary microvascular disease among perimenopausal women
Conditions
Interventions
Control group:Conventional basic therapy (antiplatelet aggregation, lipid regulation, stabilization of atherosclerotic plaques, etc., such as beta-blockers, statins, ivabradine, etc.)
Experimental group:Conventional basic therapy (such as antiplatelet aggregation lipid regulation and plaque stabilization including ß-blockers statins ivabradine etc.) plus Guanxin formula herbal gra
Sponsors
The Eighth Affiliated Hospital Sun Yat-sen University
Eligibility
Sex/Gender
Female
Age
40 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Perimenopausal women aged 40-60 years; (2) Has typical labor-induced angina symptoms; (3) Meets the diagnostic criteria for TCM phlegm syndrome; (4) Coronary CTA or contrast examination shows normal coronary arteries or stenosis <50% or residual coronary stenosis <50% after revascularization; (5) Coronary flow reserve (CFR) < 2.5 as assessed by transthoracic ultrasound examination of the anterior descending branch blood flow reserve before and after intravenous adenosine administration; (6) The patient has given informed consent to participate in this study.
Exclusion criteria
Exclusion criteria: (1) Age less than 40 years old or greater than 60 years old; (2) History of carotid endarterectomy or stent implantation history of stroke; (3) Myocarditis pericardial disease valve disease cardiomyopathy; (4) Uncontrolled diabetes (fasting blood glucose > 7.0 mmol/L); (5) Difficult-to-control hypertension (SBP > 150 mmHg and/or DBP > 90 mmHg); (6) Familial hypercholesterolemia; (7) Polyarteritis nodosa; (8) Abnormal liver function (serum GPT level more than 3.0 times the upper limit of normal) or abnormal kidney function (serum creatinine level more than 2 mg/dl); (9) Other clinically significant respiratory digestive hematologic infectious immunologic endocrine neurologic psychiatric and oncologic diseases that may pose a serious risk to patients; (10) Patients requiring warfarin anticoagulation therapy; Chinese herbal preparations that act as K channel openers and improve microcirculation; (11) Patients allergic to intravascular administration of contrast media blood or blood products; (12) Patients who are currently participating in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in coronary left anterior descending artery blood flow reserve (CFR) measured by ultrasound;Cardiac output;Six-minute walk test; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of angina attacks per week;Blood lipid levels;Six sex hormones;Vascular endothelial function indicators;Seattle Angina Scale;Menopause Quality of Life Scale;Syndrome-related indicators;TCM Syndrome Score;Other security indicators; | — |
Countries
China
Contacts
Public ContactPeng sihan
The Eighth Affiliated Hospital Sun Yat-sen University
Outcome results
None listed