Schizophrenia
Conditions
Interventions
Experimental group:On the basis of continuing the use of the original antipsychotic medications, acupuncture treatment will be incorporated, with sessions three times a week, each lasting 30 minutes,
Control group:Follow the original antipsychotic medication treatment for schizophrenia with antipsychotic drug therapy. Additionally, perform shallow needling at non-acupoint areas, three times a week
(2) On the back, at the midpoint of the line connecting Yaoyangguan and Dachangshu
(3) On the back, at the midpoint of the line connecting Mingmen and Shenshu
(4) On the lower leg, on the outer side of the calf, 3 cun below Yanglingquan, between the Gallbladder and Bladder meridians.
Sponsors
Beijing Anding Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Adult patients aged 18 to 65 years, both inpatient and outpatient, irrespective of gender, with right-handedness. (2) Diagnosis confirmation: Patients must meet the diagnostic criteria for schizophrenia as per the International Statistical Classification of Diseases and Related Health Problems (10th Revision), ICD-10. (3) Symptom profile: Participants should primarily exhibit negative symptoms, with a PANSS score =60 at baseline. The composite scale (positive scale score minus negative scale score in PANSS scale) should be <0 points, while SANS scores should be =50. (4) Medication stability: Subjects must have been receiving stable antipsychotic medication prior to enrollment, with a fixed treatment regimen. (5) Informed consent and cooperation: Both subjects and their family members or legal guardians/agents are required to provide signed informed consent indicating their willingness to participate in the study and cooperate with treatment. (6) Understanding of study details: Participants must fully comprehend the purpose, process, and potential risks associated with this study. Only those who fulfill all five aforementioned criteria simultaneously will be eligible for selection.
Exclusion criteria
Exclusion criteria: (1) have a significant physical illness; (2) Patients with substance abuse or alcohol dependence and intellectual disability; (3) Those with unstable vital signs; (4) Pregnant or lactating women or those who have allergies to acupuncture and moxibustion equipment and medications; (5) There are contraindications for MRI scans; (6) severe aphasia, agnosia, and communication impairment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Scale for Assessment of Negative Symptoms,SANS;resting state function magnetic resonance imaging,rs-fMRI; | — |
Secondary
| Measure | Time frame |
|---|---|
| Positive and Negative Syndrome Scale;Personal and Social Performance Scale;Treatment Emergent Symptom Scale; | — |
Countries
China
Contacts
Public ContactGUO Yumeng
Beijing Anding Hospital, Capital Medical University
Outcome results
None listed