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Exploring the mechanism of "spleen not rising and clearing" in spleen deficiency dampness obstruction type obesity based on the theory of "gut brain" axis

Exploring the mechanism of "spleen not rising and clearing" in spleen deficiency dampness obstruction type obesity based on the theory of "gut brain" axis

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ITMCTR
Registry ID
ITMCTR2025002076
Enrollment
Unknown
Registered
2025-10-28
Start date
2024-12-01
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Interventions

Non obese group:No

Sponsors

Guangdong Provincial Hospital of Chinese Medicine Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
35 Years to 70 Years

Inclusion criteria

Inclusion criteria: (1) Adults aged between 35-70 regardless of gender; (2) Inclusion of obese patients requires meeting the diagnostic criteria for obesity and the TCM syndrome differentiation criteria for spleen deficiency and dampness excess syndrome and being diagnosed with simple obesity through clinical examination; (3) No history of weight loss treatment within the past month (excluding diet and exercise); (4) Has good compliance and can effectively cooperate in adjusting diet exercise treatment plans and clinical examinations; (5) Complete case information and physical and chemical examination data; (6) All participants were informed of this study and signed a consent form.

Exclusion criteria

Exclusion criteria: (1) Secondary obesity caused by endocrine disorders and other diseases; (2) Pregnant or lactating women; (3) Patients with combined primary diseases of the heart cerebrovascular liver kidney and hematopoietic systems; (4) Individuals with severe mental illnesses such as schizophrenia depression anxiety etc; (5) Merge diseases that affect metabolic indicators such as Cushing's syndrome prolactinoma systemic lupus erythematosus etc; (6) Individuals who have regularly taken lipid-lowering uric acid lowering and hormonal medications within the past month; (8) The important information in the case treatment record is missing and cannot be completed. Any of the above criteria are excluded.

Design outcomes

Primary

MeasureTime frame
16S rRNA sequencing results of gut microbiota;BMI;MoCA rating;

Secondary

MeasureTime frame
5-HT;GABA;IL-1ß;IL-6;TNF-a;

Countries

China

Contacts

Public ContactLing Zhao

Guangdong Provincial Hospital of Traditional Chinese Medicine University City Hospital

1274012072@qq.com18818866015

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026