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Rhubarb Enhances Gastrointestinal Motility via Calcium-Mediated Intestinal Acetylcholine Release: A Network Pharmacology Study

A Preliminary Study Based on Network Pharmacology on How Rhubarb Regulates Acetylcholine to Improve Gastrointestinal Motility in Acute Pancreatitis

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2025002044
Enrollment
Unknown
Registered
2025-10-28
Start date
2023-03-16
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute pancreatitis

Interventions

Rhubarb:Rhubarb powder 20g dissolved in 100 ml 100 °C mixed, cooling at room temperature with gauze after filtering slag take supernatant oral, 3 times a day, 3 days
control group:100 ml normal saline orally, 3 times a day for 3 days

Sponsors

Pingxiang People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: According to the clinical diagnosis, all patients were mild to moderate; their condition was stable and did not need to be rescued; they had no communication impairment; they had no cognitive impairment; they all volunteered to participate in this study and signed an informed consent.

Exclusion criteria

Exclusion criteria: individuals under 18 years old or over 65 years old; those with other malignant tumors, cerebrovascular diseases, or severe sequelae; individuals with impaired consciousness; and those unable to communicate.

Design outcomes

Primary

MeasureTime frame
acetylcholin esterase;

Secondary

MeasureTime frame
acetylcholin;

Countries

China

Contacts

Public ContactZhiyong Wen

Pingxiang People's Hospital

729724369@qq.com15079905062

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 15, 2026