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Establishment of an Early-Warning Model of Steroid-induced Osteonecrosis of the Femoral Head Driven by Multi-modal Indicators based on the "Syndrome-Radiomics-Gene" Association

Establishment of an Early-Warning Model of Steroid-induced Osteonecrosis of the Femoral Head Driven by Multi-modal Indicators based on the "Syndrome-Radiomics-Gene" Association

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ITMCTR
Registry ID
ITMCTR2025002028
Enrollment
Unknown
Registered
2025-10-28
Start date
2025-09-08
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glucocorticoids-induced avascular necrosis of the femoral head

Interventions

Discovery Group:Hip MRI
Discovery Group:Peripheral blood collection
Verification Group:Hip MRI
Verification Group:Peripheral blood collection

Sponsors

Beijing University of Chinese Medicine Third Affiliated Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1) Continuous use of glucocorticoid therapy for =7 days within 60 days prior to enrollment; or intravenous bolus administration of =80 mg·d-1 prednisolone (or an equivalent glucocorticoid) for 3 consecutive days or more within 60 days prior to enrollment; or cumulative glucocorticoid use of =2000 mg prednisolone (or an equivalent dose of another glucocorticoid). 2) Age = 18 years, no gender restrictions; 3) Patients must sign an informed consent form to participate in the study.

Exclusion criteria

Exclusion criteria: 1) History of hip fracture; 2) Diagnosed with avascular necrosis of the femoral head and/or undergone hip surgery such as total hip arthroplasty prior to enrollment; 3) Unable to communicate normally or cooperate with follow-up visits and examinations for various reasons;

Design outcomes

Primary

MeasureTime frame
Symptoms/Traditional Chinese Medicine Syndrome Rating Scale;

Secondary

MeasureTime frame
MRI Imaging;Blood;

Countries

China

Contacts

Public ContactChen Weiheng

Beijing University of Chinese Medicine Third Affiliated Hospital

drchenweiheng@163.com010-84856226

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026