heart failure with preserved ejection fraction
Conditions
Interventions
treatment group:standard therapy plus modified Guizhi Gancao Longgu Muli decoction
Sponsors
Nanjing Municipal Health Commission
Eligibility
Sex/Gender
All
Age
50 Years to 94 Years
Inclusion criteria
Inclusion criteria: The cases were selected from patients with heart failure admitted to the Department of Cardiology of Jiangning Hospital of Traditional Chinese Medicine in Nanjing City. The inclusion criteria were as follows: (1) Admission date from January 1, 2023 to December 31, 2024; (2) LVEF = 50%; (3) Elevated BNP, along with at least one of the following evidence of cardiac structural abnormalities (left ventricular hypertrophy, left atrial enlargement, abnormal diastolic function); (4) Exclusion of other non-cardiac factors causing dyspnea, edema, etc.; (5) NYHA classification of grade II to III; (6) During the observation period, patients could adhere to outpatient follow-up, take medication on time, and had good medication compliance. (7) All enrolled patients signed the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients with heart failure not diagnosed as having "deficiency of heart yang" in traditional Chinese medicine. (2) Patients with HFrEF with LVEF 2 times the upper limit of normal. (6) Patients with moderate to severe renal function impairment (GFR = 60 ml/min or Cr = 186 µmol/L). (7) Patients with hyperkalemia before treatment (serum potassium > 5.3 mmol/L). (8) Patients with a history of angioedema related to ACEI or ARB drugs, or those with hereditary or idiopathic angioedema. (9) Pregnant or lactating women. (10) Patients with malignant tumors or other severe chronic wasting diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Minnesota Living with Heart Failure Questionnaire;6-minute walk test; | — |
Secondary
| Measure | Time frame |
|---|---|
| mitral early diastolic velocity;mitral atrial velocity;E/e' ratio;B-type natriuretic peptide;type III procollagen amino terminal peptide;Major adverse cardiovascular events; | — |
Countries
China
Contacts
Public ContactJiayang Xu
Nanjing Jiangning Hospital of Traditional Chinese Medicine
Outcome results
None listed